When nanoparticles are introduced into a physiological environment, proteins and lipids immediately cover their surface, forming a protein “corona”. It is well recognized that the corona structure influences the biological response of the body. Two deterministic models for corona formation of the human blood serum proteins around a single nanoparticle are presented and studied numerically in this paper. One of them is based on a coupled system of PDEs and involves diffusion of proteins toward the nanoparticle surface. The other one is described by ODEs and is a limit version of the first model as the protein diffusivity tends to infinity. The protein diffusivity influence on the temporal corona structure is studied in detail. Results are presented using figures and discussion.

中文翻译：

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单个纳米颗粒与人血浆蛋白相互作用的建模

当纳米颗粒被引入生理环境时，蛋白质和脂质立即覆盖其表面，形成蛋白质“电晕”。众所周知，电晕结构会影响身体的生物反应。本文提出了两种确定性模型，用于在单个纳米颗粒周围形成人血清蛋白的电晕，并对其进行了数值研究。其中之一基于 PDE 耦合系统，涉及蛋白质向纳米颗粒表面的扩散。另一个由 ODE 描述，是第一个模型的限制版本，因为蛋白质扩散率趋于无穷大。详细研究了蛋白质扩散率对时间电晕结构的影响。结果使用数字和讨论来呈现。