ABSTRACT Introduction: Recent studies have shown that pulsed electromagnetic field (EMF) has therapeutic potential for dementia, but the associated neurobiological effects are unclear. This study aimed to determine the effects of pulsed EMF on Streptozotocin (STZ)-induced dementia rats.Methods: Forty Sprague-Dawley rats were randomly allocated to one of the four groups: (i) control, (ii) normal saline injection (sham group), (iii) STZ injection (STZ group) and (iv) STZ injection with pulsed EMF exposure (PEMF, 10 mT at 20 Hz) (STZ + MF group). Morris water maze was used to assess the learning and memory abilities. Insulin growth factors 1 and 2 (IGF-1 and IGF-2) gene expression were determined by quantitative PCR. Results: The results showed that the mean escape latency in STZ-induced dementia rats was reduced by 66% under the exposure of pulsed EMF. Compared with the STZ group, the swimming distance and the time for first crossing the platform decreased by 55 and 41.6% in STZ + MF group, respectively. Furthermore, the IGF-2 gene expression significantly increased compared to that of the STZ group. Conclusions: Our findings indicate that the pulsed EMF exposure can improve the ability of learning and memory in STZ-induced dementia rats and this effect may be related to the process of IGF signal transduction, suggesting a potential role for the pulsed EMF for the amelioration of cognition impairment.

中文翻译：

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脉冲电磁场​​对STZ致痴呆大鼠学习记忆能力的影响

摘要介绍：最近的研究表明，脉冲电磁场​​ (EMF) 具有治疗痴呆症的潜力，但相关的神经生物学效应尚不清楚。本研究旨在确定脉冲 EMF 对链脲佐菌素 (STZ) 诱导的痴呆大鼠的影响。 方法：将 40 只 Sprague-Dawley 大鼠随机分配到四组之一：（i）对照组，（ii）生理盐水注射（假手术）组），（iii）STZ 注射（STZ 组）和（iv）STZ 注射，脉冲 EMF 暴露（PEMF，10 mT，20 Hz）（STZ + MF 组）。Morris水迷宫用于评估学习和记忆能力。胰岛素生长因子 1 和 2（IGF-1 和 IGF-2）基因表达通过定量 PCR 确定。结果：结果表明，在脉冲电磁场​​照射下，STZ诱导的痴呆大鼠的平均逃逸潜伏期降低了66%。与STZ组相比，STZ+MF组游泳距离和首次跨平台时间分别减少55%和41.6%。此外，与STZ组相比，IGF-2基因表达显着增加。结论：我们的研究结果表明脉冲 EMF 暴露可以提高 STZ 诱导的痴呆大鼠的学习和记忆能力，这种作用可能与 IGF 信号转导过程有关，表明脉冲 EMF 对改善痴呆的潜在作用。认知障碍。与STZ组相比，IGF-2基因表达显着增加。结论：我们的研究结果表明脉冲 EMF 暴露可以提高 STZ 诱导的痴呆大鼠的学习和记忆能力，这种作用可能与 IGF 信号转导过程有关，表明脉冲 EMF 对改善痴呆的潜在作用。认知障碍。与STZ组相比，IGF-2基因表达显着增加。结论：我们的研究结果表明脉冲 EMF 暴露可以提高 STZ 诱导的痴呆大鼠的学习和记忆能力，这种作用可能与 IGF 信号转导过程有关，表明脉冲 EMF 对改善痴呆的潜在作用。认知障碍。