Abstract Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular carrier containing high ethanol concentrations and offer improved skin permeability and efficient bioavailability due to their structure and composition. This article gives a review of ethosomes including their compositions, types, mechanism of drug delivery, stability, and safety behaviour. This article also provides a detailed overview of drug delivery applications of ethosomes in various diseases.

中文翻译：

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Ethosomes 的透皮应用——详细回顾

摘要 皮肤是人体最大的器官，是产生局部和全身作用的潜在药物递送途径。然而，皮肤的最外层角质层 (SC) 充当了一个坚韧的屏障，可防止亲水性和高分子量药物的渗透。Ethosomes 是一种新型的磷脂囊泡载体，含有高浓度的乙醇，由于其结构和组成，可提供改善的皮肤渗透性和有效的生物利用度。本文对 Ethosome 进行了综述，包括它们的组成、类型、药物递送机制、稳定性和安全行为。本文还详细概述了 ethosome 在各种疾病中的给药应用。