PURPOSE Significant cancer-related distress affects 30-60% of women diagnosed with breast cancer. Fewer than 30% of distressed patients receive psychosocial care. Unaddressed distress is associated with poor treatment adherence, reduced quality of life, and increased healthcare costs. This study aimed to evaluate the preliminary efficacy of a new web-based, psychoeducational distress self-management program, CaringGuidance™ After Breast Cancer Diagnosis, on newly diagnosed women's reported distress. METHODS One-hundred women, in five states, diagnosed with breast cancer within the prior 3 months, were randomized to 12 weeks of independent use of CaringGuidance™ plus usual care or usual care alone. The primary multidimensional outcome, distress, was measured with the Distress Thermometer (DT), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Impact of Events Scale (IES) at baseline and months 1, 2, and 3. Intervention usage was continually monitored by the data analytic system imbedded within CaringGuidance™. RESULTS Although multilevel models showed no significant overall effects, post hoc analysis showed significant group differences in slopes occurring between study months 2 and 3 on distress (F(1,70) = 4.91, p = .03, η2 = .065) measured by the DT, and depressive symptoms (F(1, 76) = 4.25, p = .043, η2 = .053) favoring the intervention. CONCLUSIONS Results provide preliminary support for the potential efficacy of CaringGuidance™ plus usual care over usual care alone on distress in women newly diagnosed with breast cancer. This analysis supports and informs future study of this self-management program aimed at filling gaps in clinical distress management.

中文翻译：

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乳腺癌诊断后的CaringGuidance™eHealth心理教育干预措施可减少早期诊断后的困扰。

目的与癌症相关的重大困扰影响被诊断出患有乳腺癌的妇女的30-60％。不到30％的患者遭受了心理社会护理。未解决的困扰与治疗依从性差，生活质量下降和医疗保健费用增加有关。这项研究旨在评估一种基于网络的心理教育窘迫自我管理程序，即乳腺癌诊断后的CaringGuidance™对新诊断的女性报告的窘迫的初步疗效。方法在五个州的一百名女性在前三个月内被诊断出患有乳腺癌，被随机分配到独立使用CaringGuidance™加上常规护理或常规护理的12周内。使用遇险温度计（DT）测量主要的多维结果即遇险，基线，第1、2和3个月的流行病学研究中心抑郁量表（CES-D）和事件影响量表（IES）。干预措施的使用由CaringGuidance™中内置的数据分析系统持续监控。结果尽管多层次模型没有显示出明显的总体影响，事后分析显示，在研究的第2个月和第3个月之间，遇险斜率存在显着的群体差异（F（1,70）= 4.91，p = .03，η2= .065）。 DT和抑郁症状（F（1，76）= 4.25，p = .043，η2= .053）有利于干预。结论结果为CaringGuidance™加上常规护理比仅常规护理对初诊乳腺癌的妇女的潜在疗效提供了初步支持。