Despite the promise of its therapeutic benefits, curcumin as a free molecule has failed to demonstrate significant clinical success. Arguably, its inherently poor stability and rapid clearance is a significant reason for these negative outcomes. The incorporation of curcumin into the backbone of a crosslinked hydrogel that utilizes poly(beta-amino ester) (PBAE) chemistry can provide a tunable protective network with the ability to release at a controlled rate while improving its therapeutic potential. Kinetics of curcumin conjugated PBAE microparticles controlled release delivery system in the presence of oxidative environments was studied for the first time, where consumption rates of active curcumin and release products were obtained. The constituent amount of curcumin present in solution was improved by incorporating the active into the network in comparison to curcumin as a free drug. Modeling curcumin conjugated PBAE microparticles will provide a design platform to improve translation and overall success in delivering a therapeutic agent that matches levels of oxidative stress.

中文翻译：

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在自由基产生系统的存在下，从受控释放的聚（β-氨基酯）微粒中模拟姜黄素的氧化消耗。

尽管有望将其作为治疗药物，但姜黄素作为一种游离分子未能证明其在临床上的成功。可以说，其固有的稳定性差和快速清除是造成这些负面结果的重要原因。将姜黄素掺入利用聚（β-氨基酯）（PBAE）化学方法的交联水凝胶的骨架中，可以提供可调的保护性网络，能够以受控的速率释放，同时提高其治疗潜力。首次研究了在氧化环境下姜黄素偶联的PBAE微粒控释递送系统的动力学，获得了活性姜黄素和释放产物的消耗率。与姜黄素作为游离药物相比，通过将活性成分掺入网络可改善溶液中姜黄素的组成量。对姜黄素缀合的PBAE微粒进行建模将提供一个设计平台，以改善翻译并在交付与氧化应激水平相匹配的治疗剂方面取得整体成功。