Reduced levels of brain derived neurotrophic factor (BDNF), through its role in neurogenesis and neuroplasticity, may be involved in the evolution and maintenance of depression. Depression has also been tied to fewer social relationships, which can vary by gender. Thus, we assessed whether the functional single nucleotide polymorphism (SNP) on the BDNF gene, Val66Met, moderated the relationship between depressive symptoms and perceived social support and unsupportive relationships, and whether these associations differed by gender. Among 945 students, (n = 667 females; n= 278 males), depressive scores were inversely related to social support, and positively related with unsupportive relations. Females reported greater social support and depressive scores compared to males. A3-way interaction was found between unsupportive relations, the Val66Met SNP, and gender, such that irrespective of genotype, females displayed astrong relationship between unsupport and depressive scores. Male Met carriers displayed this relationship, but this was less apparent among males with the Val/Val genotype. The Val66Met SNP did not moderate the link between support and depressive scores. This BDNF SNP may serve to moderate the links between psychosocial factors and depressive symptoms, but such links are nuanced, being gender-dependent and varying with the nature of the social interactions experienced.

中文翻译：

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与抑郁症状有关的社会支持和无支持的互动：性别和BDNF多态性的含义。

降低水平的脑源性神经营养因子（BDNF），通过其在神经发生和神经可塑性中的作用，可能与抑郁症的发生和维持有关。抑郁症还与较少的社会关系有关，社会关系可能因性别而异。因此，我们评估了BDNF基因Val66Met上的功能性单核苷酸多态性（SNP）是否缓解了抑郁症症状与感知的社会支持和非支持性关系之间的关系，以及这些关联是否因性别而异。在945名学生中（n = 667女； n = 278男），抑郁评分与社会支持成反比，与无支持关系成正比。与男性相比，女性报告的社交支持和抑郁评分更高。在非支持性关系之间发现了A3方式的互动，Val66Met SNP和性别，无论基因型如何，女性在不支持和抑郁评分之间都表现出强烈的关系。男性Met携带者表现出这种关系，但是在具有Val / Val基因型的男性中这种关系并不明显。Val66Met SNP不能缓解支持和抑郁评分之间的联系。这种BDNF SNP可能有助于缓和心理社会因素与抑郁症状之间的联系，但这种联系是细微的，是性别依赖性的，并随所经历的社会互动的性质而变化。Val66Met SNP不能缓解支持和抑郁评分之间的联系。这种BDNF SNP可能有助于缓和心理社会因素与抑郁症状之间的联系，但这种联系是细微的，是性别依赖性的，并随所经历的社会互动的性质而变化。Val66Met SNP不能缓解支持和抑郁评分之间的联系。这种BDNF SNP可能有助于缓和心理社会因素与抑郁症状之间的联系，但这种联系是细微的，是性别依赖性的，并随所经历的社会互动的性质而变化。