Coat proteins play multiple roles in the life cycle of a membrane-bound transport intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an acceptor compartment. The Coat Protein complex II (COPII) coat is known to act in each of these capacities, but recent work highlights the necessity for numerous accessory factors at all stages of transport carrier existence. Here, we review recent findings that highlight the roles of COPII and its regulators in the biogenesis of tubular COPII-coated carriers in mammalian cells that enable cargo transport between the endoplasmic reticulum and ER-Golgi intermediate compartments, the first step in a series of trafficking events that ultimately allows for the distribution of biosynthetic secretory cargoes throughout the entire endomembrane system.

中文翻译：

---

COPII 介导的 ER/ERGIC 界面贩运。


外壳蛋白在膜结合运输中间体的生命周期中发挥多种作用，在脂质双层重塑、货物选择和靶向受体室中发挥作用。众所周知，外壳蛋白复合物 II (COPII) 外壳在这些功能中发挥作用，但最近的研究强调了在运输载体存在的各个阶段中许多辅助因素的必要性。在这里，我们回顾了最近的研究结果，这些发现强调了 COPII 及其调节剂在哺乳动物细胞中管状 COPII 涂层载体的生物发生中的作用，这些载体使得内质网和 ER-高尔基体中间室之间的货物运输成为可能，这是一系列运输的第一步最终允许生物合成分泌货物在整个内膜系统中分布的事件。