Gout is a sign of a disturbed metabolism and associated with atrial fibrillation (AF) and other cardiovascular diseases. Our aim was to study associations between gout and cardiovascular comorbidities in patients with AF. The study population included all adults (n = 12,283) ≥ 45 years diagnosed with AF visiting 75 primary care centers in Sweden 2001–2007. Logistic regression was used to calculate odds ratios with 95% confidence intervals (CIs) for the associations between prevalent gout and cardiovascular comorbidities. In subsamples, we studied incident congestive heart failure (CHF) and ischemic stroke (IS), excluding patients with earlier registered specific diagnosis, using Cox regression (to estimate hazard ratios (HR) with 95% CIs). Gout was significantly and positively associated with CHF, obesity and diabetes among men and women, and among men also with hypertension and coronary heart disease. Prevalent gout was negatively associated with incident IS (HR and 95% CI: 0.64, 0.49–0.82; 0.50, 0.39–0.64) in both full model (adjusted for sex, age, socioeconomic factors, and comorbidities) and CHA₂DS₂-VASc model (adjusted for CHA₂DS₂-VASc, sex, and age). Adding gout to full model increased Harrell’s C by 1% in CHA₂DS₂-VASc model. In this clinical setting, we found gout to be associated with most cardiometabolic diseases except cerebrovascular diseases, and with decreased risk of IS, with gout adding significantly to the predictive value compared to CHA₂DS₂-VASc without gout included.

中文翻译：

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心房颤动患者痛风与心血管疾病的相关性。

痛风是新陈代谢紊乱的征兆，与心房颤动 (AF) 和其他心血管疾病有关。我们的目的是研究 AF 患者痛风与心血管合并症之间的关联。研究人群包括所有成年人（n = 12,283) ≥ 45 岁被诊断患有 AF 的人在 2001-2007 年访问了瑞典的 75 个初级保健中心。逻辑回归用于计算流行痛风与心血管合并症之间关联的 95% 置信区间 (CI) 的优势比。在子样本中，我们使用 Cox 回归（估计具有 95% CI 的风险比 (HR)）研究了偶发性充血性心力衰竭 (CHF) 和缺血性中风 (IS)，不包括具有早期注册特异性诊断的患者。痛风与男性和女性的 CHF、肥胖和糖尿病显着正相关，男性也与高血压和冠心病相关。在完整模型（根据性别、年龄、社会经济因素和合并症进行调整）和 CHA 中，普遍痛风与 IS 事件（HR 和 95% CI：0.64, 0.49–0.82; 0.50, 0.39–0.64）呈负相关₂ DS ₂ -VASc 模型（针对 CHA ₂ DS ₂ -VASc、性别和年龄进行了调整）。_{在 CHA 2} DS ₂ -VASc 模型中，将痛风添加到完整模型中，Harrell's C 增加了 1% 。在该临床环境中，我们发现痛风与除脑血管疾病外的大多数心脏代谢疾病相关，并且降低了 IS 的风险，与不包括痛风的 CHA ₂ DS ₂ -VASc 相比，痛风显着增加了预测值。