Sepsis-associated encephalopathy (SAE) is a common complication of sepsis. It is imperative to recognize, diagnose, and effectively manage SAE at the early stages. The aim of this study was to evaluate the potential of using the serum tau protein level in the diagnosis of SAE and the prediction of SAE outcomes. This was a retrospective and observational study. The patients included in this study were diagnosed with severe sepsis or septic shock. The serum tau protein level was measured using a commercial enzyme-linked immunosorbent assay. The association between the level of serum tau protein and SAE was assessed by multiple logistic regression analysis. One hundred nine patients with severe sepsis were enrolled during a period of two years. Of the 109 enrolled patients, 27 developed SAE. The serum tau protein level was significantly higher in the patients with SAE than that of the non-SAE group. The serum tau protein level and the sequential organ failure assessment (SOFA) score were independent factors that were associated with SAE. The combined use of the serum tau protein level with the SOFA score improved the accuracy in distinguishing SAE from non-SAE patients. A cutoff value serum tau protein level of 75.92 pg/mL had 81.1% sensitivity and 86.1% specificity in predicting the 28-day mortality in patients with severe sepsis. We identified a close association between the serum tau protein level with the appearance of SAE in patients with severe sepsis. The serum tau protein level can be useful in the prediction of poor outcomes in patients with sepsis.

中文翻译：

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严重脓毒症患者血清Tau蛋白水平升高与脓毒症相关性脑病的关系。

脓毒症相关性脑病（SAE）是脓毒症的常见并发症。必须在早期阶段识别，诊断和有效管理SAE。这项研究的目的是评估使用血清tau蛋白水平诊断SAE和预测SAE结果的潜力。这是一项回顾性研究。纳入本研究的患者被诊断出患有严重的败血症或败血性休克。使用商业酶联免疫吸附测定法测量血清tau蛋白水平。血清tau蛋白水平与SAE之间的关联通过多元逻辑回归分析进行评估。在两年期间招募了109名严重脓毒症患者。在109名患者中，有27名发展为SAE。SAE患者的血清tau蛋白水平显着高于非SAE组。血清tau蛋白水平和序贯器官衰竭评估（SOFA）评分是与SAE相关的独立因素。血清tau蛋白水平与SOFA评分的结合使用提高了区分SAE与非SAE患者的准确性。预测严重脓毒症患者28天死亡率的临界值血清tau蛋白水平为75.92 pg / mL，灵敏度为81.1％，特异性为86.1％。我们发现严重脓毒症患者的血清tau蛋白水平与SAE的出现密切相关。血清tau蛋白水平可用于预测败血症患者的不良预后。血清tau蛋白水平和序贯器官衰竭评估（SOFA）评分是与SAE相关的独立因素。血清tau蛋白水平与SOFA评分的结合使用提高了区分SAE与非SAE患者的准确性。预测严重脓毒症患者28天死亡率的临界值血清tau蛋白水平为75.92 pg / mL，灵敏度为81.1％，特异性为86.1％。我们发现严重脓毒症患者的血清tau蛋白水平与SAE的出现密切相关。血清tau蛋白水平可用于预测败血症患者的不良预后。血清tau蛋白水平和序贯器官衰竭评估（SOFA）评分是与SAE相关的独立因素。血清tau蛋白水平与SOFA评分的结合使用提高了区分SAE与非SAE患者的准确性。预测严重脓毒症患者28天死亡率的临界值血清tau蛋白水平为75.92 pg / mL，灵敏度为81.1％，特异性为86.1％。我们发现严重脓毒症患者的血清tau蛋白水平与SAE的出现密切相关。血清tau蛋白水平可用于预测败血症患者的不良预后。血清tau蛋白水平与SOFA评分的结合使用提高了区分SAE与非SAE患者的准确性。预测严重脓毒症患者28天死亡率的临界值血清tau蛋白水平为75.92 pg / mL，灵敏度为81.1％，特异性为86.1％。我们发现严重脓毒症患者的血清tau蛋白水平与SAE的出现密切相关。血清tau蛋白水平可用于预测败血症患者的不良预后。血清tau蛋白水平与SOFA评分的结合使用提高了区分SAE与非SAE患者的准确性。预测严重脓毒症患者28天死亡率的临界值血清tau蛋白水平为75.92 pg / mL，灵敏度为81.1％，特异性为86.1％。我们发现严重脓毒症患者的血清tau蛋白水平与SAE的出现密切相关。血清tau蛋白水平可用于预测败血症患者的不良预后。我们发现严重脓毒症患者的血清tau蛋白水平与SAE的出现密切相关。血清tau蛋白水平可用于预测败血症患者的不良预后。我们发现严重脓毒症患者的血清tau蛋白水平与SAE的出现密切相关。血清tau蛋白水平可用于预测败血症患者的不良预后。