Objective: Helicobacter pylori eradication is expected to prevent gastric cancer. However, morphological alterations after eradication often hinder accurate diagnosis. Therefore, we evaluated endoscopic and histological changes in gastric tumors after eradication of H. pylori in a time-dependent manner. Methods: We classified 144 cases of endoscopic submucosal dissection (ESD) of early gastric cancer into the following categories: (i) patients positive for H. pylori with no eradication history, (ii) patients positive for H. pylori who underwent ESD 2 months after eradication, (iii) patients negative for H. pylori with an eradication history of at least 6 months before ESD, and (iv) patients negative for H. pylori with an unknown history. We compared endoscopic and histological factors between the groups. Results: The characteristics of cancers positive for H. pylori were exploding shape, superficial high-grade atypical epithelium, and a surface proliferating zone. H. pylori eradication induced a series of endoscopic and histological changes, including shape depression, appearance of surface regenerative and lower-grade atypical epithelium, and a downward shift of the proliferative zone within a period as short as 2 months. Conclusion: H. pylori eradication rapidly causes cancer regression and leads to tumor shrinkage, diminished atypism, and shortened proliferative zone, resulting in drastic morphological changes.

中文翻译：

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根除幽门螺杆菌可导致早期胃腺癌的立即消退变化

目的：根除幽门螺杆菌有望预防胃癌。然而，根除后的形态学改变往往阻碍准确诊断。因此，我们以时间依赖性方式评估了根除幽门螺杆菌后胃肿瘤的内镜和组织学变化。方法：我们将 144 例早期胃癌内镜黏膜下剥离术 (ESD) 分为以下几类：(i) H. pylori 阳性且无根除史的患者，(ii) H. pylori 阳性且接受 ESD 2 个月的患者根除后，(iii) 根除 ESD 前至少 6 个月的幽门螺杆菌阴性患者，以及 (iv) 幽门螺杆菌阴性且病史未知的患者。我们比较了各组之间的内窥镜和组织学因素。结果：H. pylori 阳性癌症的特征是爆炸形状、浅表高级非典型上皮和表面增殖区。H. pylori 根除导致一系列内镜和组织学变化，包括形状凹陷、表面再生和低级别非典型上皮的出现，以及在短短 2 个月的时间内增殖区的向下移动。结论：H. pylori 根除迅速导致肿瘤消退，导致肿瘤缩小、非典型性减弱、增殖区缩短，导致形态学发生剧烈变化。表面再生和低级别非典型上皮的出现，以及在短短 2 个月内增殖区的向下移动。结论：H. pylori 根除迅速导致肿瘤消退，导致肿瘤缩小、非典型性减弱、增殖区缩短，导致形态学发生剧烈变化。表面再生和低级别非典型上皮的出现，以及在短短 2 个月内增殖区的向下移动。结论：H. pylori 根除迅速导致肿瘤消退，导致肿瘤缩小、非典型性减弱、增殖区缩短，导致形态学发生剧烈变化。