BACKGROUND Climacteric symptoms are a variety of disturbing complaints occurring during menopausal transition, many of which may be influenced by hormonal abnormalities other than related to sex steroids. AIM OF THE STUDY In this study, we investigated the association between the intensity of climacteric symptoms measured with the Kupperman index and a thyroid status. MATERIAL AND METHODS We evaluated by measuring serum thyrotropin (TSH), and free thyroxine (fT4) 202 euthyroid women admitted to the Department of Gynecological Endocrinology, Poznan University of Medical Sciences because of climacteric symptoms. Patients were both in perimenopause (n = 74) and postmenopause (n = 128), with no history of thyroid disorders. RESULTS Results presented as the mean value and standard deviation were as follows: age 54.2 ± 4.9 years, BMI 26.8 ± 4.6 kg/m2, Kupperman index 26 ± 13.1 points, TSH 2.4 ± 2.6 mU/l, fT4 1.2 ± 0.37 ng/dl. We observed a negative correlation between fT4 and the time since the last menses (R = - 0.38; p = 0.02) as well as between serum TSH concentration and sweating (R = - 0.18; p = 0.03), general weakness (R = - 0.17; p = 0.03), and palpitation (R = - 0.18; p = 0.02) and a positive correlation between fT4 and nervousness (R = 0.34; p = 0.007) and palpitations (R = 0.25; p = 0.04). In the perimenopausal subgroup, there was a positive correlation between fT4 and general weakness (R = 0.42; p = 0.03), palpitations (R = 0.50; p = 0.009), and paresthesia (R = 0.46; p = 0.01). In the postmenopausal subgroup, there was a negative correlation between TSH and sweating (R = - 0.21; p = 0.03). CONCLUSIONS Menopausal symptoms are related to thyroid status in euthyroid menopausal women.

中文翻译：

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更年期症状与更年期正常的甲状腺妇女的甲状腺状况有关。

背景技术更年期症状是在更年期过渡期间发生的各种令人不安的主诉，除了与性类固醇有关以外，其中许多可能受到荷尔蒙异常的影响。研究目的在本研究中，我们调查了用库珀曼指数测得的更年期症状强度与甲状腺状态之间的关系。材料和方法我们通过测量由于更年期症状而被波兹南医科大学妇科内分泌科收治的202名甲状腺甲状腺机能正常的妇女进行了血清促甲状腺激素（TSH）和游离甲状腺素（fT4）评估。患者均处于绝经期（n = 74）和绝经后（n = 128），无甲状腺疾病史。结果以平均值和标准差表示的结果如下：年龄54.2±4.9岁，BMI 26.8±4.6 kg / m2，库珀曼指数26±13.1点，TSH 2.4±2.6 mU / l，fT4 1.2±0.37 ng / dl。我们观察到fT4与自上一次月经以来的时间之间呈负相关（R =-0.38; p = 0.02），以及血清TSH浓度与出汗（R =-0.18; p = 0.03），全身虚弱（R =- 0.17; p = 0.03）和心pa（R =-0.18; p = 0.02）和fT4与神经质（R = 0.34; p = 0.007）和心（R = 0.25; p = 0.04）之间呈正相关。在围绝经期亚组中，fT4与全身无力（R = 0.42； p = 0.03），心（R = 0.50； p = 0.009）和感觉异常（R = 0.46； p = 0.01）之间呈正相关。在绝经后亚组中，TSH与出汗之间呈负相关（R =-0.21； p = 0.03）。结论更年期症状与正常甲状腺更年期妇女的甲状腺状况有关。