Cholesterol is one of the most vital compounds for animals as it is involved in various biological processes and acts as the structural material in the body. However, insects do not have some of the essential enzymes in the cholesterol biosynthesis pathway and this makes them dependent on dietary cholesterol. Thus, the blocking of cholesterol uptake may have detrimental effects on the survival of the insect. Utilizing this character, certain phytochemicals can be used to inhibit mosquito sterol carrier protein-2 (AeSCP-2) activity via competitive binding and proven to have effective insecticidal activities against disease-transmitting mosquitoes and other insect vectors. A range of synthetic compounds, phytochemicals, and synthetic analogs of phytochemicals are found to have AeSCP-2 inhibitory activity. Phytochemicals such as alpha-mangostin can be considered as the most promising group of compounds when considering the minimum environmental impact and availability at a low cost. Once the few limitations such as very low persistence in the environment are addressed successfully, these chemicals may be used as an effective tool for controlling mosquitoes and other disease-transmitting vector populations.

中文翻译：

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基于甾醇载体蛋白抑制的蚊媒控制：当前的知识和未来的前景。

胆固醇是动物最重要的化合物之一，因为它参与各种生物过程并在体内充当结构材料。但是，昆虫在胆固醇的生物合成途径中没有某些必需的酶，这使它们依赖于饮食中的胆固醇。因此，阻断胆固醇的摄取可能对昆虫的生存产生不利影响。利用此特性，某些植物化学物质可通过竞争性结合来抑制蚊固醇载体蛋白2（AeSCP-2）的活性，并被证明对传播疾病的蚊子和其他昆虫载体具有有效的杀虫活性。发现许多合成化合物，植物化学物质和植物化学物质的合成类似物具有AeSCP-2抑制活性。考虑到对环境的最小影响和低成本的可获得性，植物化学药品（例如α-芒果）可被视为最有前途的化合物。一旦成功解决了一些局限性，例如在环境中的持久性极低，这些化学药品就可以用作控制蚊子和其他传播疾病的媒介种群的有效工具。