SHIP-1 is a hematopoietic-specific inositol phosphatase activated downstream of a multitude of receptors including those for growth factors, cytokines, antigen, immunoglobulin and toll-like receptor agonists where it exerts inhibitory control. While it is constitutively expressed in all immune cells, SHIP-1 expression is negatively regulated by the inflammatory and oncogenic micro-RNA miR-155. Knockout mouse studies have shown the importance of SHIP-1 in various immune cell subsets and have revealed a range of immune-mediated pathologies that are engendered due to loss of SHIP-1’s regulatory activity, impelling investigations into the role of SHIP-1 in human disease. In this review, we provide an overview of the literature relating to the role of SHIP-1 in hematopoietic cell signaling and function, we summarize recent reports that highlight the dysregulation of the SHIP-1 pathway in cancers, autoimmune disorders and inflammatory diseases, and lastly we discuss the importance of SHIP-1 in restraining myeloid growth factor signaling.

SHIP-1是一种造血特异性肌醇磷酸酶，在多种受体的下游被激活，包括生长因子，细胞因子，抗原，免疫球蛋白和toll样受体激动剂，在这些受体中发挥抑制作用。虽然SHIP-1在所有免疫细胞中组成性表达，但它们受到炎症和致癌性微小RNA miR-155的负调控。敲除小鼠研究显示了SHIP-1在各种免疫细胞亚群中的重要性，并揭示了由于SHIP-1调节活性的丧失而引起的一系列免疫介导的病理学，促使人们对SHIP-1在人类中的作用进行了研究疾病。在这篇综述中，我们提供了有关SHIP-1在造血细胞信号传导和功能中的作用的文献综述，