Circadian clocks drive daily rhythms of physiology and behavior in multiple organisms and synchronize these rhythms to environmental cycles of light and temperature. The basic mechanism of the clock consists of a transcription-translation feedback loop, in which key clock proteins negatively regulate their own transcription. Although much of the focus with respect to clock mechanisms has been on the regulation of transcription and on the stability and activity of clock proteins, it is clear that other regulatory processes also have to be involved to explain aspects of clock function. Here, we review the role of alternative splicing in circadian clocks. Starting with a discussion of the Drosophila clock and then extending to other major circadian model systems, we describe how the control of alternative splicing enables organisms to maintain their circadian clocks as well as to respond to environmental inputs, in particular to temperature changes.

中文翻译：

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拼接时钟以维持和引导昼夜节律。


昼夜节律时钟驱动多种生物体的日常生理和行为节律，并使这些节律与光和温度的环境周期同步。时钟的基本机制由转录-翻译反馈环组成，其中关键的时钟蛋白负向调节其自身的转录。尽管时钟机制的大部分焦点都集中在转录调控以及时钟蛋白的稳定性和活性上，但很明显，还必须涉及其他调控过程来解释时钟功能的各个方面。在这里，我们回顾了选择性剪接在生物钟中的作用。我们从果蝇时钟的讨论开始，然后扩展到其他主要的昼夜节律模型系统，描述了选择性剪接的控制如何使生物体能够维持其昼夜节律钟以及对环境输入做出反应，特别是对温度变化。