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The Effects of Plasmacytoid Dendritic Cell-Stimulative Lactic Acid Bacteria, Lactococcus lactis Strain Plasma, on Exercise-Induced Fatigue and Recovery via Immunomodulatory Action.
International Journal of Sport Nutrition and Exercise Metabolism ( IF 3.0 ) Pub Date : 2019-07-01 , DOI: 10.1123/ijsnem.2018-0377
Takeshi Kokubo 1 , Yuta Komano 1 , Ryohei Tsuji 1 , Daisuke Fujiwara 1 , Toshio Fujii 1 , Osamu Kanauchi 1
Affiliation  

The unique lactic acid bacteria, Lactococcus lactis strain plasma (LC-Plasma), stimulates plasmacytoid dendritic cells, which play an important role in viral infection. The authors previously reported that LC-Plasma reduced the number of days athletes experienced cold-like symptoms and fatigue feelings after high-intensity exercise training; however, the mechanism was unclear. In this study, the authors investigated the effect of LC-Plasma on recovery from physical damage after single exercise on a treadmill in BALB/c mice model. Oral administration of LC-Plasma (AIN-93G + 0.029% LC-Plasma) for 4 weeks significantly improved the locomotor reduction after treadmill exercise. This effect was not detected in mice receiving Lactobacillus rhamnosus GG, representative probiotics strain. LC-Plasma also improved voluntary locomotor activity after exercise. Blood and muscle sample analysis indicated that LC-Plasma affects plasmacytoid dendritic cell activation, which, in turn, attenuates muscle degenerative genes and the concentration of fatigue-controlled cytokine transforming growth factor-β.

中文翻译:

浆细胞样树突状细胞刺激性乳酸菌乳酸乳球菌菌株血浆对运动诱发的疲劳和免疫调节作用的恢复的影响。

独特的乳酸菌乳酸乳球菌血浆(LC-Plasma)刺激浆细胞样树突状细胞,这在病毒感染中起重要作用。作者先前曾报道,LC-Plasma减少了运动员在进行高强度运动训练后经历感冒样症状和疲劳感的天数;但是,机制尚不清楚。在这项研究中,作者研究了LC-等离子对在BALB / c小鼠模型中的跑步机上单次运动后从身体损伤中恢复的影响。口服LC-血浆(AIN-93G + 0.029%LC-血浆)4周可显着改善跑步机运动后运动能力的降低。在接受鼠李糖乳杆菌GG(代表性益生菌菌株)的小鼠中未检测到这种作用。LC-Plasma还改善了运动后的自主运动能力。
更新日期:2019-11-01
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