Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.

中文翻译：

---

开始抗逆转录病毒治疗的印尼HIV患者认知健康的决定因素。

在艾滋病毒感染者中已经描述了认知障碍，并且对抗逆转录病毒疗法（ART）可以保持稳定，但是在患有巨细胞病毒高负担的开始进行ART的年轻成年人中尚未进行认知障碍的监测。我们在印度尼西亚雅加达招募了80名开始接受抗逆转录病毒治疗的受试者，其中CD <200 CD4 T细胞/μL。认知功能（Z评分）开始较低，但在ART上有所改善，六个月后趋于稳定，除记忆功能外，所有领域均有所改善。巨细胞病毒在ART上的负担（通过抗体水平评估）与基线时的Z分数（尤其是记忆功能）成反比。在线性混合模型中，Z分数的提高受年龄，学历和CD4 T细胞计数的影响。