Typography-like templates for polydimethylsiloxane (PDMS) microfluidic chips using a fused deposition modeling (FDM) three-dimensional (3D) printer are presented. This rapid and fast proposed scheme did not require complicated photolithographic fabrication facilities and could deliver resolutions of ~100 μm. Polylactic acid (PLA) was adopted as the material to generate the 3D-printed units, which were then carefully assembled on a glass substrate using a heat-melt-curd strategy. This craft of bonding offers a cost-effective way to design and modify the templates of microfluidic channels, thus reducing the processing time of microfluidic chips. Finally, a flexible microfluidic chip to be employed for cell-based drug screening was developed based on the modularized 3D-printed templates. The lithography-free, typography-like, 3D-printed templates create a modularized fabrication process and promote the prevalence of integrated microfluidic systems with minimal requirements and improved efficiency.

中文翻译：

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像印刷术一样的3D打印模板，可无光刻地制造微流控芯片。

提供了使用熔融沉积建模（FDM）三维（3D）打印机的聚二甲基硅氧烷（PDMS）微流体芯片的类印刷模板。这种快速，快速提出的方案不需要复杂的光刻制造设施，并且可以提供〜100μm的分辨率。采用聚乳酸（PLA）作为生成3D打印单元的材料，然后使用热熔固化策略将其小心地组装在玻璃基板上。这种键合工艺提供了一种经济高效的方法来设计和修改微流体通道的模板，从而减少了微流体芯片的处理时间。最后，基于模块化的3D打印模板，开发了用于基于细胞的药物筛选的柔性微流控芯片。无光刻，类印刷，