Introduction: The 5-hydroxytryptamine 2C receptor (HTR2C) rs6318 polymorphism has been associated with increased sensitivity to stress. This study investigated whether the rs6318 genotype modified the cortisol response to endurance physical activity. Methods: The HTR2C SNP was genotyped in a population of agonistic cyclists, and salivary cortisol levels were measured before and after an endurance competition. Results and Conclusion: Salivary cortisol levels increased after the competition (from 20.72 ± 12.36 ng/mL to 33.80 ± 21.53 ng/mL; p = 3.189 × 10–5). rs6318 C carriers displayed higher baseline cortisol levels compared to G carriers (26.60 ± 9.35 ng/mL vs. 19.50 ± 12.63 ng/mL; p = 0.04). Baseline cortisol levels were able to predict the cortisol response to exercise (β = –0.846; p = 1.2 × 10–5). Although regression analysis did not identify an association between HTR2C genotype and change in cortisol levels, a secondary analysis in which the population was classified by median cortisol changes suggested that they might be weakly associated, thus warranting further investigation.

中文翻译：

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耐力体力活动后HTR2C基因变异和唾液皮质醇水平：一项初步研究

简介：5-羟色胺 2C 受体 (HTR2C) rs6318 多态性与对压力的敏感性增加有关。这项研究调查了 rs6318 基因型是否会改变皮质醇对耐力体力活动的反应。方法：HTR2C SNP 在一群激动的自行车手中进行基因分型，并在耐力赛前后测量唾液皮质醇水平。结果和结论：比赛后唾液皮质醇水平增加（从 20.72 ± 12.36 ng/mL 到 33.80 ± 21.53 ng/mL；p = 3.189 × 10-5）。与 G 载体相比，rs6318 C 载体显示出更高的基线皮质醇水平（26.60 ± 9.35 ng/mL 与 19.50 ± 12.63 ng/mL；p = 0.04）。基线皮质醇水平能够预测皮质醇对运动的反应（β = –0.846；p = 1.2 × 10–5）。