This study aimed to prepare a novel quartz crystal microbalance (QCM) sensor for the detection of pirimicarb. Pirimicarb-imprinted poly (ethylene glycol dimethacrylate-N-metacryloyl-(l)-tryptophan methyl ester) [p (EGDMA-MATrp)] nanofilm (MIP) on the gold surface of a QCM chip was synthesized using the molecular imprinting technique. A nonimprinted p (EGDMA-MATrp) nanofilm (NIP) was also synthesized using the same experimental technique. The MIP and NIP nanofilms were characterized via Fourier transform infrared spectroscopy attenuated total reflectance spectroscopy, contact angle, atomic force microscopy, and an ellipsometer. A competitive adsorption experiment on the sensor was performed to display the selectivity of the nanofilm. An analysis of the QCM sensor showed that the MIP nanofilm exhibited high sensitivity and selectivity for pirimicarb determination. A liquid chromatography-tandem mass spectrometry method was prepared and validated to determine the accuracy and precision of the QCM sensor. The accuracy and precision of both methods were determined by a comparison of six replicates at three different concentrations to tomato samples extracted by using a Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method. The limit of detection of the QCM sensor was found to be 0.028 nM. In conclusion, the QCM sensor showed good accuracy, with recovery percentages between 91 and 94%. Also, the pirimicarb-imprinted QCM sensor exhibited a fast response time, reusability, high selectivity and sensitivity, and a low limit of detection. Therefore, it offers a serious alternative to the traditional analytical methods for pesticide detection in both natural sources and aqueous solutions.

中文翻译：

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一种基于分子印迹纳米膜的石英晶体微天平传感器，用于实时检测嘧啶威。

这项研究旨在制备一种新型的石英晶体微天平（QCM）传感器，用于检测吡虫威。使用分子印迹技术在QCM芯片的金表面上合成了由吡虫威威印制的聚（甲基丙烯酸乙二醇酯-N-甲基丙烯酰基-（l）-色氨酸甲酯）[p（EGDMA-MATrp）]纳米膜（MIP）。还使用相同的实验技术合成了非印迹p（EGDMA-MATrp）纳米膜（NIP）。通过傅立叶变换红外光谱，衰减全反射光谱，接触角，原子力显微镜和椭偏仪对MIP和NIP纳米膜进行了表征。在传感器上进行了竞争性吸附实验，以显示纳米膜的选择性。对QCM传感器的分析表明，MIP纳米膜对吡虫威确定具有较高的灵敏度和选择性。制备并验证了液相色谱-串联质谱法，以确定QCM传感器的准确性和精密度。两种方法的准确度和精密度是通过将三种不同浓度下的六个重复样品与通过快速，简便，廉价，有效，坚固和安全（QuEChERS）方法提取的番茄样品进行比较而确定的。发现QCM传感器的检测极限为0.028nM。总之，QCM传感器显示出良好的准确性，回收率在91％至94％之间。同样，吡虫威印迹的QCM传感器显示出快速的响应时间，可重复使用性，高选择性和灵敏度以及低检测限。因此，