Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease,Journal of Neuroradiology

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Aquaporin 4 distribution in the brain and its relevance for the radiological appearance of neuromyelitis optica spectrum disease
Journal of Neuroradiology ( IF 3.0 ) Pub Date : 2019-04-11 , DOI: 10.1016/j.neurad.2019.03.015
Roxana Ameli ₁ , Charles R G Guttmann ₂ , Juan Carlos Prieto ₂ , Fabien Rollot ₃ , Miklos Palotai ₂ , Sandra Vukusic ₄ , Romain Marignier ₅ , François Cotton ₆ , , ,

Affiliation

Background and purpose

To determine the precise incidence of lesions at sites of high Aquaporin-4 expression (hAQP4) and their possible association with known neuromyelitis optica spectrum disease (NMOSD) lesions patterns.

Materials and methods

A retrospective analysis of brain and, when available, spinal cord MRI scans of 54 NMOSD patients recruited among the French NMOSD cohort was performed. Brain lesions were annotated as MS-like, non-specific, or evocative of NMOSD. The topography of hAQP4 was reassessed by human brain atlas. The incidence of lesions in hAQP4 and their association with lesions evocative of NMOSD was estimated.

Results

Among those included (41/54 female, mean age: 45 years) 47/54 (87%) presented brain lesions. Twenty-six/47 (55%) had lesions in hAQP4. Thirty-two/54 patients (60%) had lesions considered evocative of NMOSD. The majority of them also presented lesions in hAQP4 (65%, 21/32). Patients with lesions in hAQP4 and lesions evocative of NMOSD demonstrated more extensive myelitis compared to the other patients (7 [6–10] versus 4 [3–5] vertebral segments, P = 0.009).

Conclusion

The coexistence of lesions evocative of NMOSD and in hAQP4 is associated with significantly more extensive myelitis, and might have pathophysiological and clinical significance.

中文翻译：

水通道蛋白 4 在大脑中的分布及其与视神经脊髓炎谱系疾病放射学表现的相关性

背景和目的

确定水通道蛋白 4 高表达 (hAQP4) 部位病变的精确发生率及其与已知视神经脊髓炎谱系疾病 (NMOSD) 病变模式的可能关联。

材料和方法

对法国 NMOSD 队列中招募的 54 名 NMOSD 患者的脑部和脊髓 MRI 扫描进行了回顾性分析。脑损伤被注释为 MS 样、非特异性或 NMOSD 唤起。人脑图谱重新评估了 hAQP4 的形貌。估计了 hAQP4 病变的发生率及其与 NMOSD 病变的关联。

结果

其中包括（41/54 女性，平均年龄：45 岁）47/54（87%）出现脑损伤。26/47 (55%) 在 hAQP4 中有病变。32/54 名患者 (60%) 有被认为是 NMOSD 的病变。他们中的大多数人还出现了 hAQP4 病变（65%，21/32）。与其他患者相比，具有 hAQP4 病变和 NMOSD 病变的患者表现出更广泛的脊髓炎（7 [6-10] 对 4 [3-5] 椎节段，P = 0.009）。