The association of the anti-aquaporin-4 (AQP-4) water channel antibody with neuromyelitis optica (NMO) syndrome has been described from various parts of the world. There has been no large study describing this association from southern Africa, an HIV endemic area. HIV patients often present with visual disturbance or features of a myelopathy but seldom both either simultaneously or consecutively. We report our experience of NMO in the era of AQP-4 testing in HIV-positive and HIV-negative patients seen in KwaZulu-Natal, South Africa.

中文翻译：

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南非夸祖鲁纳塔尔省 HIV 血清反应阳性和血清反应阴性患者的视神经脊髓炎表现和水通道蛋白 4 抗体。

世界各地已经描述了抗水通道蛋白 4 (AQP-4) 水通道抗体与视神经脊髓炎 (NMO) 综合征的关联。南部非洲是艾滋病毒流行区，目前还没有大型研究描述这种关联。HIV 患者经常出现视觉障碍或脊髓病的特征，但很少同时或连续出现。我们报告了我们在南非夸祖鲁纳塔尔省看到的 HIV 阳性和 HIV 阴性患者的 AQP-4 检测时代的 NMO 经验。