This study investigated the magneto- and electroencephalography (MEG and EEG, respectively) resting state to identify the deviations closely associated with the deficit syndrome (DS) in schizophrenia patients. Ten subjects in each group (control, DS, and nondeficit schizophrenia [NDS]) were included. Subjects underwent MEG-EEG recordings during a resting state condition. MEG coherence source imaging (CSI) in source space and spectral analysis in sensor space were performed. Significant differences were found between the 2 patient groups: (1) MEG and EEG spectral analysis showed significantly higher power at low frequencies (delta band) at sensor space in DS compared with NDS patients; (2) source analysis revealed larger power in the DS compared with NDS group at low frequencies in the frontal region; (3) NDS patients showed significantly higher MEG signal relative power in beta bands in sensor space compared with DS patients; (4) both DS and NDS patients showed higher EEG absolute power at higher beta band compared to controls; and (5) patients with DS were found to have a significantly higher MEG CSI than controls in the beta frequency band. These data support the observation of increased power in the low-frequency EEG/MEG rhythms associated with the DS. Increased power in the beta rhythms was more associated with the NDS.

中文翻译：

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缺陷与非缺陷精神分裂症：静息状态和源相干性的 MEG-EEG 调查——初步数据

本研究调查了脑磁图和脑电图（分别为 MEG 和 EEG）静息状态，以确定与精神分裂症患者的缺陷综合征 (DS) 密切相关的偏差。每组包括十名受试者（对照组、DS 和非缺陷型精神分裂症 [NDS]）。受试者在静息状态下进行 MEG-EEG 记录。进行了源空间中的 MEG 相干源成像 (CSI) 和传感器空间中的光谱分析。两个患者组之间存在显着差异：（1）MEG 和 EEG 频谱分析显示，与 NDS 患者相比，DS 传感器空间的低频（delta 波段）功率显着更高；(2) 源分析显示，在额叶区的低频下，DS 组与 NDS 组相比功率更大；(3) NDS患者与DS患者相比，传感器空间β波段MEG信号相对功率显着更高；(4) 与对照组相比，DS 和 NDS 患者在较高的 β 波段显示出更高的 EEG 绝对功率；(5) 发现 DS 患者的 MEG CSI 显着高于 beta 频带中的对照组。这些数据支持观察到与 DS 相关的低频 EEG/MEG 节律的功率增加。Beta 节律的功率增加与 NDS 更相关。这些数据支持观察到与 DS 相关的低频 EEG/MEG 节律的功率增加。Beta 节律的功率增加与 NDS 更相关。这些数据支持观察到与 DS 相关的低频 EEG/MEG 节律的功率增加。Beta 节律的功率增加与 NDS 更相关。