Objective

To explore the possible etiology of multiple osteomata on a skull and long bones from an individual from a medieval site in Tuscany, Italy.

Materials

Human skeletal remains dating to the 10^th–12^th century AD from the parish church of S. Pietro in Pava, in the province of Siena (Tuscany, Central Italy).

Methods

Macroscopic and imaging analyses (Cone Beam Computed Tomography).

Results

Nine round-shaped new bone formations are observed on a female individual aged 40–50 years. The lesions have a smooth surface and range from 2.2–6 mm in diameter.

Conclusions

Cone Beam Computed Tomography confirmed that the lesions were composed of compact bone. Macroscopic and radiological features suggest the presence of nonsyndromic multiple osteomata.

Significance

Single cranial osteomata are commonly observed in osteoarchaeological remains, but multiple osteomata are rare and might assist in our understanding of neoplastic conditions in the past.

Limitations

The lack of soft tissues prevents the diagnosis of complex disorders, such as the Gardner syndrome, which is characterised by multiple osteomata and polyposis of the colon.

Suggestions for further research

Careful investigation and reporting of all neoplastic lesions in ancient human remains in order to increase our knowledge about the etiology in past human populations.

中文翻译：

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来自中世纪托斯卡纳，意大利（公元10-12日）的多个骨瘤。

目的

探索来自意大利托斯卡纳中世纪遗址的一个人的头骨和长骨上的多个骨瘤的可能病因。

用料

人类遗骨可追溯至10^个-12^个世纪的广告S.彼得在帕瓦教区教堂，在锡耶纳（托斯卡纳，意大利中部）的省份。

方法

宏观和成像分析（锥形束计算机断层扫描）。

结果

在40至50岁的女性个体上观察到9个圆形的新骨形成。病变表面光滑，直径范围为2.2-6 mm。

结论

锥形束计算机断层扫描证实病变是由致密骨组成。宏观和放射学特征提示存在非综合征性多发性骨瘤。

意义

单头颅骨瘤通常在骨考古遗迹中观察到，但多发性骨瘤很少见，可能有助于我们了解过去的肿瘤状况。

局限性

软组织的缺乏阻止了复杂疾病的诊断，例如以多发性骨瘤和结肠息肉为特征的Gardner综合征。

进一步研究的建议

仔细调查和报告古代人类遗骸中的所有赘生性病变，以增加我们对过去人类的病因学的了解。