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Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes.
Biomedical Research ( IF 1.3 ) Pub Date : 2019-04-16 , DOI: 10.2220/biomedres.40.79
Toshihiko Iwanaga 1 , Junko Nio-Kobayashi 1 , Hiromi Takahashi-Iwanaga 1
Affiliation  

The vitreous of perinatal mice temporarily develops a unique vascular system, called the vasa hyaloidea propria (VHP). Observations showed the vessels possessed an extracellular matrix including the basement membrane in their entire length. Immunostaining of whole mount preparations of VHP with integrin β1 antibody displayed a bush-like network consisting of long and straight fibers which were associated with the VHP but extended apart from the blood vessels. Electron microscopically, each fiber was composed of a bundle of thin filaments different from collagen fibrils. Macrophages associated with the VHP appeared to be arrested by the integrin bushes. The integrin bushes fragmented and disappeared by postnatal day 10, just before the regression of the VHP. Macrophages were involved in the digestion and clearance of integrin bushes. The vitreous integrin bushes appear to provide a scaffold for architectural maintenance of the hyaloid vessels and macrophages.

中文翻译:

布什样的整合素细丝网络与小鼠新生眼中的玻璃样血管相关。

围生期小鼠的玻璃体暂时发育出独特的血管系统,称为透明血管膜(VHP)。观察表明,血管具有细胞外基质,包括整个长度的基底膜。用整联蛋白β1抗体对VHP的整装制剂进行免疫染色,显示出一个丛状的网络,该网络由长而直的纤维组成,这些纤维与VHP相关,但与血管分开。在电子显微镜下,每根纤维由一束不同于胶原纤维的细丝组成。与VHP相关的巨噬细胞似乎被整联蛋白灌木丛所阻滞。整合素灌木丛在出生后第10天即VHP消退之前破碎并消失。巨噬细胞参与整合素灌木的消化和清除。
更新日期:2019-11-01
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