Aim

The aim was to analyze emotional state, cognitive functioning and quality of life (QoL) of adult women with Turner syndrome (TS) in Lithuania.

Patients and methods

Of all invited adult TS patients from Lithuanian TS database (n = 150), 68 (age 18–60, average 30.2 ± 9.0 years) agreed and were recruited for the study, as well as 68 age-matched healthy control women. Emotional state was evaluated by Profile of Mood States (POMS) questionnaire, cognitive functioning by Trail Making Test and Digit Span Test (DST) of Wechsler Adult Intelligence Scale, and QoL by WHO Brief Quality of Life Questionnaire (WHO QoL).

Results

Patients with TS were of a significantly shorter stature (p < .001) than age-matched control women and than the 3rd percentile of the National Standards of Lithuania.

After the adjustment for height, weight and body mass index (BMI), no significant differences in emotional state were detected, though without the adjustment, depression-dejection (p = .004) score was significantly higher in TS women than in age-matched controls. Significantly worse cognitive functioning (attention capacity, visual scanning abilities, executive function and psychomotor speed, p < .001), as well as worse psychological (p = .002) and social (p = .006) aspects of QoL were found after the adjustment for height, weight and BMI in adult women with TS than in age-matched controls.

Conclusion

In conclusion, after the adjustment for height, weight and BMI, adult women with Turner syndrome in Lithuania have impaired cognitive functioning and worse psychological and social aspects of QoL, but not emotional state and physical and environmental aspects of QoL in comparison to age-matched healthy women.

中文翻译：

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立陶宛特纳综合征成年女性的情绪状态，认知功能和生活质量。

目标

目的是分析立陶宛患有特纳综合征（TS）的成年女性的情绪状态，认知功能和生活质量（QoL）。

患者和方法

在立陶宛TS数据库中所有受邀的成人TS患者（n  = 150）中，有68名（年龄18-60岁，平均30.2±9.0岁）同意并被招募参加研究，以及68名年龄匹配的健康对照女性。情绪状态通过情绪状态档案（POMS）问卷进行评估，认知功能通过Wechsler成人智力量表的追踪测试和数字跨度测试（DST）进行评估，并通过WHO生存质量简短问卷（WHO QoL）进行QoL。

结果

TS患者的身材显着短 于年龄匹配的对照女性（p <.001），并且比立陶宛国家标准的第3个百分位低。

调整身高，体重和体重指数（BMI）后，没有发现情绪状态的显着差异，尽管不进行调整， TS女性的抑郁-沮丧（p = .004）得分显着高于年龄匹配的女性控制。 在QoL之后，发现QoL的认知功能明显变差（注意能力，视觉扫描能力，执行功能和心理运动速度，p  <.001），以及较差的心理（p  = .002）和社会（p = .006）方面。与年龄匹配的对照组相比，对成年TS妇女的身高，体重和BMI进行了调整。

结论

总之，在调整身高，体重和体重指数之后，立陶宛特纳综合征的成年女性损害了认知功能，并且QoL的心理和社会方面较差，但与年龄匹配的人相比，QoL的情感状态，身体和环境方面没有恶化健康的女性。