Tachykinins (TKs) include an evolutionarily conserved group of small bio-active peptides which possess a common carboxyl-terminal sequence, Phe-X-Gly-Leu-Met-NH2. TKs also have been shown to have implications in different steps of carcinogenesis, such as angiogenesis, mitogenesis, metastasis, and other growth-related events. The biological actions of substance P (SP), as the most important member of the TK family, are mainly mediated through a G protein-coupled receptor named neurokinin-1 receptor (NK1R). More recently, it has become clear that SP/NK1R system is involved in the initiation and activation of signaling pathways involved in cancer development and progression. Therefore, SP may contribute to triggering a variety of effector mechanisms including protein synthesis and a number of transcription factors that modulate the expression of genes involved in these processes. The overwhelming insights into the blockage of NK1R using specific antagonists could suggest a therapeutic approach in cancer therapy. In this review, we focus on evidence supporting an association between the signaling pathways of the SP/NK1R system and cancer cell proliferation and development.

中文翻译：

---

P /神经激肽-1受体信号传导途径在肿瘤细胞生长和发育中的新兴作用。

速激肽（TK）包括一组进化保守的小生物活性肽，这些肽具有共同的羧基末端序列Phe-X-Gly-Leu-Met-NH2。还已经证明传统知识在致癌的不同步骤中具有影响，例如血管生成，有丝分裂，转移和其他与生长有关的事件。作为TK家族中最重要的成员，物质P（SP）的生物学作用主要通过称为神经激肽-1受体（NK1R）的G蛋白偶联受体介导。最近，很明显，SP / NK1R系统参与了癌症发展和进程中信号通路的启动和激活。因此，SP可能有助于触发各种效应子机制，包括蛋白质合成和许多转录因子，这些因子调节参与这些过程的基因的表达。关于使用特异性拮抗剂阻断NK1R的大量见解可能暗示了癌症治疗的一种治疗方法。在这篇综述中，我们集中于支持SP / NK1R系统信号通路与癌细胞增殖与发展之间关联的证据。