Induced pluripotent stem cells (iPSCs) can be differentiated into multiple cell types in the body while maintaining proliferative capabilities. The generation of hepatocyte-like cells (HLCs) from iPSCs has resulted in a new source for liver cells. Since healthy primary human hepatocytes and hepatic cells are difficult to obtain, HLCs are gaining attention. HLCs can be obtained from a continuous, stable source while maintaining their original donor genotype, which opens new avenues into patient-specific testing and therapeutics. Studies have utilized HLCs for toxicity testing to further understand their drug metabolizing capabilities. This review focuses on advances being made to achieve hepatic functions from HLCs, their current use in hepatotoxicity testing, and their potential for future liver-related toxicity evaluations.

中文翻译：

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人类诱导的多能干细胞衍生肝细胞在毒性试验中的研究进展。

诱导多能干细胞（iPSC）可以在体内分化为多种细胞类型，同时保持增殖能力。从iPSC产生的肝细胞样细胞（HLC）导致了肝细胞的新来源。由于难以获得健康的原代人肝细胞和肝细胞，因此HLC受到关注。可以从连续，稳定的来源获得HLC，同时保持其原始供体基因型，这为针对患者的测试和治疗开辟了新途径。研究已利用HLC进行毒性测试，以进一步了解其药物代谢能力。这篇综述着重于从HLC实现肝功能的进展，它们在肝毒性测试中的当前用途以及它们在未来与肝脏相关的毒性评估中的潜力。