Accumulating evidence suggest that excessive reactive oxygen species-induced oxidative damage may underlie neurodegeneration and cognitive impairment in several disorders including schizophrenia. In this study we examined the association of oxidative stress with cognitive deficits in first-episode drug-naïve (FEDN) patients with schizophrenia. We recruited 54 FEDN patients and 50 age- and sex-matched healthy controls and examined the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus cognitive Battery (MCCB) and plasma total antioxidant status (TAS). Psychopathological symptoms were assessed using the Positive and Negative Syndrome Scale. The results showed that plasma TAS levels were significantly lower in the patients than those in the healthy subjects (94.7 ± 25.0 U/ml vs 156.6 ± 46.7 U/ml, p < 0.0001). The patients scored lower than healthy controls on the MCCB total score, speed of processing, attention/vigilance and managing emotion test index and STROOP test. For the patients, TAS was associated with some domains of cognitive deficits in schizophrenia, such as speed of processing, attention/vigilance and emotion managing. Our results suggested that oxidative stress may be involved in the pathophysiology of schizophrenia at the early of stage and its cognitive impairment.

中文翻译：

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首次接受药物治疗的精神分裂症患者血浆总抗氧化剂水平和认知障碍。

越来越多的证据表明，在包括精神分裂症在内的多种疾病中，过量的活性氧引起的氧化损伤可能是神经退行性变和认知障碍的基础。在这项研究中，我们研究了首次发作的未曾患过精神分裂症的患者中氧化应激与认知缺陷的关系。我们招募了54名FEDN患者和50名年龄和性别相匹配的健康对照者，并研究了改善精神分裂症共识认知电池（MCCB）和血浆总抗氧化剂状态（TAS）认知的测量和治疗研究。使用阳性和阴性综合征量表评估心理病理症状。结果显示，患者的血浆TAS水平显着低于健康受试者（94.7±25.0 U / ml对156.6±46.7 U / ml，p  <0.0001）。患者的MCCB总分，处理速度，注意力/警觉和管理情绪测试指数以及STROOP测试得分均低于健康对照组。对于患者而言，TAS与精神分裂症的某些认知缺陷有关，例如处理速度，注意力/警觉性和情绪管理。我们的结果表明，氧化应激可能与精神分裂症的早期病理生理及其认知障碍有关。