当前位置: X-MOL 学术Curr. Opin. Behav. Sci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Brain mechanisms mediating effects of stress on reward sensitivity.
Current Opinion in Behavioral Sciences ( IF 4.9 ) Pub Date : 2018-02-22 , DOI: 10.1016/j.cobeha.2018.01.016
Maria Ironside 1, 2 , Poornima Kumar 1, 2 , Min-Su Kang 1 , Diego A Pizzagalli 1, 2
Affiliation  

Acute and chronic stress have dissociable effects on reward sensitivity, and a better understanding of these effects promises to elucidate the pathophysiology of stress-related disorders, particularly depression. Recent preclinical and human findings suggest that stress particularly affects reward anticipation; chronic stress perturbates dopamine signaling in the medial prefrontal cortex and ventral striatum; and such effects are further moderated by early adversities. Additionally, a systems-level approach is uncovering the interplay among striatal, limbic and control networks giving rise to stress-related, blunted reward sensitivity. Together, this cross-species confluence has not only enriched our understanding of stress-reward links but also highlighted the role of neuropeptides and opioid receptors in such effects, and thereby identified novel targets for stress-related neuropsychiatric disorders.



中文翻译:

调节压力对奖励敏感性影响的大脑机制。

急性和慢性压力对奖赏敏感性具有独立的影响,更好地理解这些影响有望阐明压力相关疾病(尤其是抑郁症)的病理生理学。最近的临床前和人类研究结果表明,压力尤其会影响奖励预期。慢性压力扰乱内侧前额皮质和腹侧纹状体的多巴胺信号传导;早期的逆境进一步减弱了这种影响。此外,系统级方法正在揭示纹状体、边缘和控制网络之间的相互作用,从而导致与压力相关的、钝化的奖励敏感性。总之,这种跨物种的融合不仅丰富了我们对压力-奖励联系的理解,而且还强调了神经肽和阿片受体在这种效应中的作用,从而确定了与压力相关的神经精神疾病的新靶标。

更新日期:2018-02-22
down
wechat
bug