Drosophila melanogaster has recently been developed as a simple, in vivo, genetic model of chemotherapy-induced peripheral neuropathy. Flies treated with the chemotherapy agent cisplatin display both a neurodegenerative phenotype and cell death in rapidly dividing follicles, mimicking the cell specific responses seen in humans. Cisplatin induces climbing deficiencies and loss of fertility in a dose dependent manner. Drosophila sensitivity to cisplatin in both cell types is affected by genetic background. We show that mutation or RNAi-based knockdown of genes known to be associated with CIPN incidence in humans affect sensitivity of flies to CIPN. Drosophila is a promising model with which to study the effect of genetics on sensitivity to CIPN.

果蝇最近已被开发为一种化学疗法诱导的周围神经病的简单的体内遗传模型。用化学药剂顺铂处理过的果蝇在快速分裂的卵泡中既表现出神经变性表型，又表现出细胞死亡，模仿了人类所见的细胞特异性反应。顺铂以剂量依赖性方式引起攀登缺陷和生育力丧失。果蝇对两种细胞类型对顺铂的敏感性受遗传背景的影响。我们表明，突变或基于RNAi的基因敲低已知与人类中的CIPN发生率相关，会影响果蝇对CIPN的敏感性。果蝇是一种有前途的模型，可用于研究遗传学对CIPN敏感性的影响。