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Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses.
Acta Cytologica ( IF 1.6 ) Pub Date : 2019-07-30 , DOI: 10.1159/000501421
Erika F Rodriguez 1 , Ricardo Pastorello 2 , Lais Osmani 3 , Mark Hopkins 3 , Maria Kryatova 3 , Satomi Kawamoto 4 , Zahra Maleki 3
Affiliation  

INTRODUCTION Pulmonary adenocarcinoma is a major cause of mortality worldwide. The majority of patients present with advanced stage disease, and minimally invasive procedures are desirable for diagnosis and treatment plans. Herein, we report our experience with percutaneous/transthoracic needle aspiration (TT-NA) in the cytologic diagnosis of pulmonary adenocarcinoma. MATERIAL AND METHODS After institutional review board approval, the cytopathology electronic data system was searched for all consecutive TT-NA of the lung masses from January 2011 to November 2015. Patients' medical records were reviewed and cytologic materials were evaluated. RESULTS A total of 151 specimens were identified, with a mean age of 62.8 years; 62.9% of the patients had a prior history of malignancy. Carcinoma/adenocarcinoma was the most common (80%) diagnosis. The targeted lesions were predominantly located in the lung (56.3%, 81/151) and pleural based (27.8%, 42/151). The mean size of the lesions was 3.6 cm. Cytology specimens were adequate in 70.9% of the cases, while 72.8% (110/151) of the cases also had concurrent core biopsy. A malignant diagnosis was rendered in the majority of the cases (64.9%). In 71% of the cases, immunohistochemistry/histochemistry studies were successfully performed. Molecular/genetic studies were requested in 80% of the cases and had adequate material. Complications of the procedure were seen in 9.9% of the patients including pneumothorax (7.9%) and hemoptysis (1.9%). CONCLUSION TT-NA is a relatively safe and reliable technique in the assessment of pulmonary lesions.

中文翻译:

超声引导的经胸细针抽吸术:一种诊断和定量分析肺肿块的可靠工具。

引言肺腺癌是全世界死亡的主要原因。大多数患有晚期疾病的患者以及微创手术是诊断和治疗计划所需要的。在此,我们报告经皮/经胸针穿刺术(TT-NA)在肺腺癌的细胞学诊断中的经验。材料与方法经机构审查委员会批准,从细胞病理学电子数据系统中检索2011年1月至2015年11月所有连续的TT-NA肺肿块。检查患者的病历并评估细胞学资料。结果共鉴定出151个标本,平均年龄为62.8岁。62.9%的患者有恶性病史。癌/腺癌是最常见的诊断(80%)。靶向病变主要位于肺部(56.3%,81/151)和基于胸膜的病变(27.8%,42/151)。病变的平均大小为3.6厘米。在70.9%的病例中,细胞学标本足够,而在同时进行核心活检的病例中,有72.8%(110/151)病例。大多数病例(64.9%)被诊断为恶性。在71%的病例中,免疫组织化学/组织化学研究已成功进行。80%的病例要求进行分子/遗传学研究,并具有足够的材料。9.9%的患者出现了手术并发症,包括气胸(7.9%)和咯血(1.9%)。结论TT-NA是评估肺部病变的相对安全可靠的技术。病变的平均大小为3.6厘米。在70.9%的病例中,细胞学标本足够,而在同时进行核心活检的病例中,有72.8%(110/151)病例。大多数病例(64.9%)被诊断为恶性。在71%的病例中,免疫组织化学/组织化学研究已成功进行。80%的病例要求进行分子/遗传学研究,并具有足够的材料。9.9%的患者出现了手术并发症,包括气胸(7.9%)和咯血(1.9%)。结论TT-NA是评估肺部病变的相对安全可靠的技术。病变的平均大小为3.6厘米。在70.9%的病例中,细胞学样本足够,而在同时进行核心活检的病例中,有72.8%(110/151)。大多数病例(64.9%)被诊断为恶性。在71%的病例中,免疫组织化学/组织化学研究已成功进行。80%的病例要求进行分子/遗传学研究,并具有足够的材料。9.9%的患者出现了手术并发症,包括气胸(7.9%)和咯血(1.9%)。结论TT-NA是评估肺部病变的相对安全可靠的技术。大多数病例(64.9%)被诊断为恶性。在71%的病例中,免疫组织化学/组织化学研究已成功进行。80%的病例要求进行分子/遗传学研究,并具有足够的材料。9.9%的患者出现了手术并发症,包括气胸(7.9%)和咯血(1.9%)。结论TT-NA是评估肺部病变的相对安全可靠的技术。大多数病例(64.9%)被诊断为恶性。在71%的病例中,免疫组织化学/组织化学研究已成功进行。80%的病例要求进行分子/遗传学研究,并具有足够的材料。9.9%的患者出现了手术并发症,包括气胸(7.9%)和咯血(1.9%)。结论TT-NA是评估肺部病变的相对安全可靠的技术。
更新日期:2019-11-01
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