Eisosomes are furrows in the yeast plasma membrane that form a membrane domain with distinct lipid and protein composition. Recent studies highlighted the importance of this domain for the regulation of proton-nutrient symporters. The amino acids and other nutrients, which these transporters deliver to the cytoplasm not only feed into metabolic pathways but also activate the metabolic regulator TORC1. Eisosomes have also been shown to harbor the membrane stress sensors Slm1 and Slm2. Membrane tension caused by hypoosmotic shock results in the redistribution of Slm1/2 from eisosomes to TORC2 which in turn regulates lipid synthesis. Therefore, eisosomes function upstream of both TORC1 and TORC2 regulation.

中文翻译：

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异构体位于TORC1和TORC2调控的交集。

异质体是酵母质膜中的犁沟，形成具有独特脂质和蛋白质组成的膜结构域。最近的研究强调了该域对于调节质子营养同质体的重要性。这些转运蛋白传递到细胞质的氨基酸和其他营养物质不仅进入代谢途径，而且激活了代谢调节因子TORC1。脂质体也显示出带有膜应力传感器Slm1和Slm2。低渗性休克引起的膜张力导致Slm1 / 2从异构体重新分布到TORC2，进而调节脂质合成。因此，异构体在TORC1和TORC2调控的上游起作用。