Emerging evidence present credible support in favour of the potential role of mahanine and girinimbine. Non-toxic herbal carbazole alkaloids occur in the edible part of Murraya koenigii, Micromelum minutum, M. zeylanicum, and M. euchrestiolia. Mahanine and girinimbine are the major potent compounds from these species. In fact, they interfered with tumour expansion and metastasis development through down-regulation of apoptotic and antiapoptotic protein, also involved in the stimulation of cell cycle arrest. Consequently, these compounds were well proven for the in-vitro and in vivo evaluation that could be developed as novel agents either alone or as an adjuvant to conventional therapeutics. Therefore, mahanine and girinimbine analogs have the potential to be the promising chemopreventive agents for the tumour recurrence and the treatment of human malignancies. In this review, an updated wide-range of pleiotropic anticancer and biological effects induction by mahanine and girinimbine against cancer cells were deeply summarized.

中文翻译：

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Mahanine和Girinimbine类似物的多效性：抗癌机制及其治疗用途。

新兴证据提供了可靠的支持，支持了甘露碱和吉利比滨的潜在作用。无毒草药咔唑生物碱存在于Murraya koenigii，Micromelum minutum，M。zeylanicum和M. euchrestiolia的可食部分。玛哈宁和吉利宁是这些物种的主要有效成分。实际上，它们通过下调凋亡和抗凋亡蛋白来干扰肿瘤的扩展和转移的发展，这也参与了细胞周期阻滞的刺激。因此，这些化合物已在体外和体内评估中得到了充分证明，可以单独或作为常规疗法的佐剂开发为新型药物。因此，玛哈宁和吉利宁比类似物有可能成为有希望的化学预防剂，用于肿瘤复发和人类恶性肿瘤的治疗。在这篇综述中，深度总结了更新的多效抗癌作用范围，以及由麻黄碱和吉利比滨对癌细胞的生物学效应诱导。