Abstract To develop a novel asymmetric organocatalyst based on a ribonucleoside skeleton, we designed and synthesized 2′-aminouridine derivatives. The synthesized 2′-aminouridines having bulky substituents at both base and sugar moieties could catalyze the Diels-Alder reaction between cinnamaldehyde and cyclopentadiene. However, the optical purities of the resulting products were unexpectedly low.

中文翻译：

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合成 2'-氨基尿苷衍生物作为 Diels-Alder 反应的有机催化剂

摘要 为了开发一种基于核糖核苷骨架的新型不对称有机催化剂，我们设计并合成了 2'-氨基尿苷衍生物。合成的2'-氨基尿苷在碱基和糖部分都具有大取代基，可以催化肉桂醛和环戊二烯之间的Diels-Alder反应。然而，所得产物的光学纯度出乎意料地低。