Abstract

To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (1–8) were isolated from the mother liquid. The chemical structures of new compounds (1–4) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC₅₀ values ranging from 4.02 to 15.80 μM.

Graphic Abstract

中文翻译：

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来自升麻根茎的细胞毒性环阿丹三萜皂苷。

 抽象的

为了富集具有生物活性的环阿麻烷三萜糖苷actein，并寻找更多具有细胞毒性的环阿麻烷三萜，对升麻进行了植物化学研究。通过重结晶纯化得到113g（ 0.17 %）肌动蛋白，同时从母液中分离出8种环阿麻烷型三萜（ 1-8 ）。通过 1D 和 2D NMR 以及 HRESIMS 光谱分析阐明了新化合物 ( 1 – 4 ) 的化学结构。此外，新化合物对 5 种人类癌细胞系表现出中等和广谱的细胞毒性，IC ₅₀值范围为 4.02 至 15.80 μM 。

 图文摘要