Chronic kidney disease (CKD) is recognized as a worldwide health problem. Progression of CKD may lead to many serious complications, which are associated with increased morbidity and mortality. Presently, there is no satisfactory treatment. Thus, targeted therapies are urgently needed. The kidneys are second to the heart in terms of mitochondrial abundance and oxygen consumption. Thus, it is not surprising that mitochondrial homeostasis is absolutely essential for the normal function of the kidney. In fact, a number of reports indicate that mitochondria are involved in the progression of CKD. In this review, we summarize our current knowledge on mitochondrial homeostasis in CKD. We also provide an update on recent developments in the field of mitochondria-targeting therapeutic approaches against CKD.

中文翻译：

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慢性肾脏疾病中线粒体稳态的破坏：一项小型综述。

慢性肾脏病（CKD）被认为是全球性的健康问题。CKD的进展可能导致许多严重的并发症，这与发病率和死亡率增加有关。目前，还没有令人满意的治疗方法。因此，迫切需要靶向治疗。就线粒体丰度和耗氧量而言，肾脏仅次于心脏。因此，线粒体稳态对于肾脏的正常功能绝对必不可少。实际上，许多报告表明线粒体参与了CKD的发展。在这篇综述中，我们总结了目前关于CKD线粒体稳态的知识。我们还提供了针对CKD的线粒体靶向治疗方法领域的最新进展。