The mammalian gut epithelium displays among the highest rates of self‐renewal, with a turnover time of less than 5 days. Renewal involves concerted proliferation at the bottom of the crypt, migration and differentiation along the crypt‐villus axis and anoïkis/shedding in the luminal epithelium. Renewal is controlled by interplay between signalling pathways, among which canonical and non‐canonical Wnt signals play prominent roles. Overall 92% of colon tumours show increased canonical Wnt signalling resulting from mutations, established as major driver steps towards carcinogenesis.

中文翻译：

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非典型 RhoU/Wrch1 Rho GTPase 控制肠道上皮细胞增殖和凋亡

哺乳动物肠道上皮显示出最高的自我更新率，周转时间不到 5 天。更新包括隐窝底部的协同增殖、沿隐窝-绒毛轴的迁移和分化以及腔上皮细胞的脱落/脱落。更新受信号通路之间的相互作用控制，其中经典和非经典 Wnt 信号起着重要作用。总体而言，92% 的结肠肿瘤显示出由突变引起的典型 Wnt 信号增加，这是致癌的主要驱动步骤。