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Genetic diversity of HLA system in six populations from Mexico City Metropolitan Area, Mexico: Mexico City North, Mexico City South, Mexico City East, Mexico City West, Mexico City Center and rural Mexico City.
Human Immunology ( IF 3.1 ) Pub Date : 2019-07-25 , DOI: 10.1016/j.humimm.2019.07.297
Rodrigo Barquera 1 , Julio César Martínez-Álvarez 2 , Diana Iraíz Hernández-Zaragoza 3 , Alicia Bravo-Acevedo 4 , Francisco Juárez-Nicolás 5 , Agustín Jericó Arriaga-Perea 6 , María Del Rosario Vega-Martínez 7 , Andrea Ortega-Yáñez 8 , Gamaliel Benítez-Arvizu 9 , Esteban Arrieta-Bolaños 10 , Stephen Clayton 11 , Eva Dolores Juárez-Cortés 6 , Concepción López-Gil 12 , Raquel García-Álvarez 13 , María Araceli Arrazola-García 2 , Virginia Martínez-Bezies 14 , Vicencio Juárez-Barreto 15 , Flor Del Rocío Ramos-de la Cruz 12 , Rosa María Macías-Medrano 6 , Patricia Méndez-Mani 12 , Ariadna Escutia-González 5 , Gustavo Daniel Montiel-Hernández 16 , Alexander Immel 17 , María de Los Ángeles Pavón-Vargas 12 , Norma Salgado-Galicia 7 , Bárbara Novelo-Garza 18 , Joaquín Zúñiga 19 , Edmond J Yunis 20 , Carolina Bekker-Méndez 21 , Julio Granados 22
Affiliation  

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1217 Mexicans from the Mexico City Metropolitan Area living in the northern (N = 751), southern (N = 52), eastern (N = 79), western (N = 33), and central (N = 152) Mexico City, and rural communities (N = 150), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes include 11 Native American haplotypes. Admixture estimates revealed that the main genetic components are Native American (63.85 ± 1.55% by ML; 57.19% of Native American haplotypes) and European (28.53 ± 3.13% by ML; 28.40% of European haplotypes), and a less apparent African genetic component (7.61 ± 1.96% by ML; 7.17% of African haplotypes).



中文翻译:

来自墨西哥墨西哥城大都会区的六个种群中HLA系统的遗传多样性:墨西哥城北,墨西哥城南,墨西哥城东,墨西哥城西,墨西哥城中心和墨西哥城郊。

我们研究了HLA I类(HLA-A-B)和II类(HLA-DRB1-DQB1)基于PCR-SSP的等位基因来自居住在北部(N = 751),南部(N = 52),东部(N = 79),西部(N = 33)和中部的墨西哥城大都会地区的1217名墨西哥人(N = 152)墨西哥城和乡村社区(N = 150),以获取有关等位基因和单倍型频率的信息。我们发现,最常见的单倍型包括11个美国原住民单倍型。外加剂估计显示,主要的遗传成分是美洲原住民(按ML分类为63.85±1.55%;美国原住民单倍型为57.19%)和欧洲(按ML分类为28.53±3.13%;欧洲单倍型为28.40%),以及非洲遗传成分较少(按ML测得为7.61±1.96%;占非洲单倍型的7.17%)。

更新日期:2019-07-25
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