Chronic peripheral elevation of interleukin 6 (IL-6) in humans is associated with cognitive deficits. 4- and 24-month-old IL-6-deficient C57BL/6J (IL-6KO) and reference wild-type (WT) mice were tested in an object recognition test. Discrimination ratios and recognition indexes were significantly lower in 4-month-old IL-6KO and in 24-month-old WT mice vs 4-month-old WT animals. Their discrimination ratios had negative values and recognition indexes were below 50% indicating inability to differentiate the novel from the familiar object after 1-hour delay. In 24-month-old IL-6KO mice recognition index reached 53.17% indicating that their recognition memory was not worsened with age in comparison with younger IL-6-deficient animals. Results of holeboard and elevated plus maze indicated that this effect was memory specific. Inborn IL-6 deficiency attenuated recognition memory in 4-month-old mice and did not altered recognition memory in aged animals. IL-6 signalling may constitute a target for development of the protection against memory disturbances connected with IL-6 overexpression.

中文翻译：

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IL-6缺乏对年轻成年小鼠和老年小鼠认知记忆的意义。

人类白细胞介素6（IL-6）的慢性周围性升高与认知缺陷有关。在对象识别测试中测试了4个月和24个月大的IL-6缺陷型C57BL / 6J（IL-6KO）和参考野生型（WT）小鼠。与4个月大的WT动物相比，4个月大的IL-6KO和24个月大的WT小鼠的辨别率和识别指数明显更低。他们的辨别率均为负值，识别指数低于50％，表明在延迟1小时后无法将小说与熟悉的对象区分开。在24个月大的IL-6KO小鼠中，识别指数达到53.17％，这表明与年轻的IL-6缺陷动物相比，它们的识别记忆力并未随着年龄的增长而恶化。洞洞板和高架迷宫的结果表明，这种效应是记忆特异性的。先天性IL-6缺乏会减弱4个月大小鼠的识别记忆，而不会改变老年动物的识别记忆。IL-6信号传导可能构成开发针对与IL-6过表达相关的记忆障碍的保护的目标。