Hepatocellular carcinoma (HCC) is the second leading cause of mortality among cancers. It has been found that long noncoding RNAs (lncRNAs) are involved in many human cancers, including liver cancer. It has been identified that carcinogenic and tumor-suppressing lncRNAs are associated with complex processes in liver cancer. These lncRNAs may participate in a variety of pathological and biological activities, such as cell proliferation, apoptosis, invasion, and metastasis. Here, we review the regulation and function of lncRNA in liver cancer and evaluate the potential of lncRNA as a new goal for liver cancer.

中文翻译：

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与肝细胞癌相关的长非编码RNA的最新研究进展。

肝细胞癌（HCC）是癌症中第二大死因。已经发现长的非编码RNA（lncRNA）与许多人类癌症包括肝癌有关。已经确定致癌和抑制肿瘤的lncRNA与肝癌的复杂过程有关。这些lncRNA可能参与多种病理和生物学活动，例如细胞增殖，凋亡，侵袭和转移。在这里，我们审查了肝癌中lncRNA的调控和功能，并评估了lncRNA作为肝癌新目标的潜力。