RNase 7 is a skin-derived antimicrobial peptide expressed in various epithelial tissues. It is upregulated by stimulation with microbes and pro-inflammatory cytokines. Herein, we examined the expression levels of RNase 7 in tissues from normal and inflamed oral epithelia and salivary glands via immunohistochemistry. RNase 7 was expressed mainly in the surface layers of the parakeratinized and orthokeratinized oral epithelium. In addition, it was strongly and weakly expressed in oral lichen planus and radicular cysts, respectively. RNase 7 was constitutively expressed in salivary glands, particularly in the serous and duct cells. In the case of Sjogren's syndrome, RNase 7 was strongly expressed in serous, ductal, and mucous cells in areas with lymphocytic infiltration. The localization patterns of RNase 7 were similar to those of other epithelial antimicrobial peptides, including beta-defensins. Thus, epithelial antimicrobial peptides may act against microbial infections in a coordinated manner in oral epithelia and salivary glands.

中文翻译：

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正常和发炎的口腔上皮细胞和唾液腺中RNase 7的免疫组织化学定位。

RNase 7是一种在多种上皮组织中表达的源自皮肤的抗菌肽。它被微生物和促炎性细胞因子刺激而上调。在这里，我们通过免疫组织化学检查了正常和发炎的口腔上皮和唾液腺组织中RNase 7的表达水平。RNase 7主要在角化和角质化口腔上皮的表层表达。另外，它在口腔扁平苔藓和放射状囊肿中分别有强表达和弱表达。RNase 7在唾液腺，尤其是浆液和导管细胞中组成性表达。在干燥综合征的情况下，RNase 7在淋巴细胞浸润区域的浆液，导管和粘液细胞中强烈表达。RNase 7的定位模式与包括β-防御素在内的其他上皮抗菌肽的定位模式相似。因此，上皮抗微生物肽可以在口腔上皮和唾液腺中以协同方式对抗微生物感染。