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Effects of testosterone on circadian rhythmicity in old mice.
The Journal of Physiological Sciences ( IF 2.6 ) Pub Date : 2019-07-12 , DOI: 10.1007/s12576-019-00695-4
Atsuyoshi Hashimoto 1 , Shingo Fujiki 1 , Wataru Nakamura 2 , Takahiro J Nakamura 1
Affiliation  

Serum testosterone concentration decreases with age in humans and rodents. Accordingly, old male mice show changes in locomotor activity rhythms: a lengthened free-running period and decreased activity levels among others. To investigate whether testosterone replacement improves the age-related decline in circadian rhythmicity, we examined the effects of testosterone on the circadian rhythms of wheel running activity in old male mice. Intact male C57BL/6J mice (18-22 months old) were subcutaneously implanted with silicone tubes packed with testosterone propionate (TP) or cholesterol. TP treatment significantly decreased the daily wheel running revolutions in a normal light/dark (LD) cycle and in constant darkness (DD), but did not affect the free-running period. The same experiment performed on young male gonadectomized mice (3-5 months old) demonstrated that TP treatment significantly increased activity levels in both LD and DD. These results suggest that testosterone replacement exacerbates the age-related decline in circadian rhythmicity.

中文翻译:


睾酮对老年小鼠昼夜节律的影响。



人类和啮齿动物的血清睾酮浓度随着年龄的增长而降低。因此,老年雄性小鼠表现出运动活动节律的变化:自由奔跑时间延长和活动水平降低等。为了研究睾酮替代是否可以改善与年龄相关的昼夜节律下降,我们研究了睾酮对老年雄性小鼠轮跑活动昼夜节律的影响。完整的雄性 C57BL/6J 小鼠(18-22 个月大)皮下植入装有丙酸睾酮 (TP) 或胆固醇的硅胶管。 TP处理显着降低了正常光/暗(LD)循环和持续黑暗(DD)下的每日车轮运行转数,但不影响自由运行期。对年轻雄性腺切除小鼠(3-5 个月大)进行的相同实验表明,TP 治疗显着提高了 LD 和 DD 的活动水平。这些结果表明,睾酮替代会加剧与年龄相关的昼夜节律下降。
更新日期:2019-11-01
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