OBJECTIVE Anogenital warts are caused by human papillomavirus (HPV). Globally, HPV genotypes 6 and 11 are most often associated with anogenital warts. However, the diversity of HPV genotypes found in patients with genital warts in Thailand is unknown. The aim of this study was to investigate HPV-associated anogenital warts in the Thai population and to assess whether genotypes found are represented in the bivalent and quadrivalent HPV vaccine. METHODS This study included 206 anogenital swab samples from patients who were diagnosed with anogenital warts. Detection of HPV DNA was performed using polymerase chain reaction to amplify the L1 gene and sequencing. RESULTS HPV was identified in 88.3% (182/206) of the samples. The majority of HPV genotypes were low-risk genotypes HPV6 (36.9%) and HPV11 (36.4%), which represented the most common infection found in genital warts in this study. CONCLUSION Immunization with the quadrivalent vaccine (HPV6, HPV11, HPV16, and HPV18) could potentially prevent genital warts caused by HPV infection.

中文翻译：

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泰国患有肛门生殖器疣的男女中的人乳头瘤病毒。

目的肛门生殖器疣是由人乳头瘤病毒（HPV）引起的。在全球范围内，HPV基因型6和11最常与肛门生殖器疣相关。但是，在泰国的尖锐湿疣患者中发现的HPV基因型的多样性尚不清楚。这项研究的目的是调查泰国人口中与HPV相关的肛门生殖器疣，并评估在二价和四价HPV疫苗中是否发现了基因型。方法该研究包括206例被诊断患有肛门生殖器疣的患者的肛门生殖器拭子样本。HPV DNA的检测使用聚合酶链反应扩增L1基因并进行测序。结果在88.3％（182/206）的样本中鉴定出HPV。HPV基因型的大多数为低风险基因型HPV6（36.9％）和HPV11（36.4％），这代表了本研究中尖锐湿疣中最常见的感染。结论使用四价疫苗（HPV6，HPV11，HPV16和HPV18）进行免疫可以潜在地预防由HPV感染引起的生殖器疣。