Ferroptosis is a nonapoptotic form of cell death characterized by the iron-dependent accumulation of toxic lipid reactive oxygen species. Small-molecule screening and subsequent optimization have yielded potent and specific activators and inhibitors of this process. These compounds have been employed to dissect the lethal mechanism and implicate this process in pathological cell death events observed in many tissues, including the brain. Indeed, ferroptosis is emerging as an important mechanism of cell death during stroke, intracerebral hemorrhage, and other acute brain injuries, and may also play a role in certain degenerative brain disorders. Outstanding issues include the practical need to identify molecular markers of ferroptosis that can be used to detect and study this process in vivo, and the more basic problem of understanding the relationship between ferroptosis and other forms of cell death that can be triggered in the brain during injury.

中文翻译：

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铁死亡和脑损伤。

铁死亡是一种非凋亡形式的细胞死亡，其特征是铁依赖性有毒脂质活性氧的积累。小分子筛选和随后的优化已经产生了该过程的有效且特异性的激活剂和抑制剂。这些化合物已被用来剖析致死机制，并将这一过程与在包括大脑在内的许多组织中观察到的病理性细胞死亡事件联系起来。事实上，铁死亡正在成为中风、脑出血和其他急性脑损伤期间细胞死亡的重要机制，并且也可能在某些退行性脑部疾病中发挥作用。悬而未决的问题包括识别铁死亡分子标记的实际需要，这些标记可用于检测和研究体内这一过程，以及理解铁死亡与其他形式的细胞死亡之间的关系的更基本问题，这些细胞死亡可以在大脑中触发受伤。