PURPOSE To evaluate the relationship between wrist circumference, markers of adipose dysfunction, and cardiovascular risk in youths with obesity. METHODS In this cross-sectional study, we measured body mass composition by dual-energy X-ray absorptiometry, wrist circumference, waist-to-height ratio, fasting blood insulin, glucose, lipid profile, adiponectin, and leptin in 280 children with overweight/obesity and without diabetes (age: 7-18 years). Cardiovascular risk was estimated by "metabolic syndrome score" (MetS score). RESULTS Study participants had median [25th-75th percentile] wrist circumference of 17.5 [16.7-18.5] cm and waist-to-height ratio of 0.62 [0.59-0.67]. Lower adiponectin-leptin ratio was found among subjects in the upper 50th percentiles of wrist circumference [0.17 (0.09-0.36) vs. 0.38 (0.16-0.79); p < 0.001]. Wrist circumference was independently associated with MetS score (r = 0.5 p < 0.001). Among MetS score components, an independent association between wrist circumference HDLc, triglycerides, and systolic blood pressure was found (r = - 0.253 p < 0.001; r =+ 0.204 p < 0.001; r = + 0.403 p = < 0.001, respectively). The coefficient of determination for MetS score was nominally higher when considering wrist circumference as independent variable (Adj-R2 = 0.30) then when considering body mass index SD (Adj-R2 = 0.28), waist-to-height ratio (Adj-R2 = 0.26) or truncal fat percentage (Adj-R2 = 0.01). The addition of wrist circumference in age and gender adjusted models, accounting to any other anthropometric parameters, resulted in a significant improvement of the Adj-R2 (p < 0.001 for all). CONCLUSIONS Our study shows that wrist circumference independently relates to adiponectin-leptin ratio and to the prediction of cardiovascular risk, suggesting it as an efficient and adjunctive anthropometric marker of cardiometabolic risk in children with obesity.

中文翻译：

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腕围是肥胖儿童肥胖组织功能障碍和心血管风险的生物标志。

目的评估肥胖青年中手腕周长，脂肪功能障碍标志物和心血管风险之间的关系。方法在这项横断面研究中，我们通过双能X射线吸收法，腕围，腰围与身高比，空腹血胰岛素，葡萄糖，脂质分布，脂联素和瘦素测量了280名体重超重儿童的体重组成/肥胖且无糖尿病（年龄：7-18岁）。通过“代谢综合征评分”（MetS评分）评估心血管风险。结果研究参与者的中位腕围[25-75％]为17.5 [16.7-18.5] cm，腰高比为0.62 [0.59-0.67]。在腕部上半部的第50个百分位数中，脂联素与瘦素的比例较低[0.17（0.09-0.36）对0.38（0.16-0.79）；p <0.001]。腕围与MetS评分独立相关（r = 0.5 p <0.001）。在MetS评分组件中，发现腕围HDLc，甘油三酸酯和收缩压之间存在独立的关联（r =-0.253 p <0.001； r ​​= + 0.204 p <0.001； r ​​= + 0.403 p = <0.001）。当将腕围作为自变量（Adj-R2 = 0.30）时，将MetS评分的确定系数从名义上提高，然后在考虑体重指数SD（Adj-R2 = 0.28），腰高比（Adj-R2 = 0.26）或截尾脂肪百分比（Adj-R2 = 0.01）。考虑到其他人体测量学参数，在年龄和性别调整的模型中增加了腕围，导致Adj-R2的显着改善（所有p均<0.001）。