We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 2827 Mexicans from the state of Puebla living in the city of Puebla (N = 1994) and rural communities (N = 833), to obtain information regarding allelic and haplotypic frequencies. We found that the 16 most frequent haplotypes in Puebla are all of them Native American. Admixture estimates revealed that the main genetic components in the state of Puebla are Native American (72.21 ± 1.25% by ML; 63.30% of Native American haplotypes) and European (21.05 ± 1.92% by ML; 23.86% of European haplotypes), and a less prominent African genetic component (6.74 ± 2.20% by ML; 6.20% of African haplotypes).

我们通过基于PCR-SSP的分型方法研究了HLA I类（HLA-A，-B）和II类（HLA-DRB1，-DQB1）等位基因，来自居住在普埃布拉市（N = 1994）的2827名墨西哥人和农村社区（N = 833），以获取有关等位基因和单倍型频率的信息。我们发现普埃布拉州最常见的16个单倍型都是美洲原住民。外加剂估计显示，普埃布拉州的主要遗传成分是美洲原住民（按ML分类为72.21±1.25％;美国原住民单倍型为63.30％）和欧洲（按ML分类为21.05±1.92％;欧洲单倍型为23.86％），以及不太显着的非洲遗传成分（按ML值，为6.74±2.20％；非洲单倍型的6.20％）。