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Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche.
Human Immunology ( IF 3.1 ) Pub Date : 2019-07-22 , DOI: 10.1016/j.humimm.2019.07.281
Rodrigo Barquera 1 , Julio Lara-Riegos 2 , Komathi Sree Ponnandai-Shanmugavel 3 , Alexander Immel 4 , Esteban Arrieta-Bolaños 5 , Stephen Clayton 3 , Raúl Solís-Martínez 6 , Alicia Bravo-Acevedo 7 , Tannya Verónica Vázquez-Castillo 6 , Diana Iraíz Hernández-Zaragoza 8 , María Del Rosario Vega-Martínez 9 , Norma Salgado-Galicia 9 , Carolina Elizabeth Medina-Escobedo 10 , Joaquín Zúñiga 11 , Edmond J Yunis 12 , Carolina Bekker-Méndez 13 , Julio Granados 14
Affiliation  

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 81 Mexicans from the state of Campeche living in the city of Campeche (N = 34) and rural communities (N = 47), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Campeche include ten Native American, three European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Campeche are Native American (65.56 ± 0.96% by ML; 51.24% of Native American haplotypes), European (34.44 ± 10.94% by ML; 30.25% of European haplotypes), and a virtually absent African genetic component (0.00 ± 10.31% by ML; 9.26% of African haplotypes).



中文翻译:

来自墨西哥坎佩切州的两个种群中HLA系统的遗传多样性:坎佩切市和坎佩切州农村。

我们研究了HLA I类(HLA-A-B)和II类(HLA-DRB1-DQB1)等位基因,基于PCR-SSP的方法,从居住在坎佩切州(N = 34)和农村社区(N = 47)的坎佩切州的81名墨西哥人中获得有关等位基因和单倍型频率的信息。我们发现,坎佩切州最常见的单体型包括10个美洲原住民,3个欧洲,1个非洲和1个亚洲单体型。外加剂估计显示,坎佩切州的主要遗传成分是美洲原住民(按ML分类为65.56±0.96%;美国原住民单倍型为51.24%),欧洲(按ML分类为34.44±10.94%;欧洲单倍型为30.25%)和几乎不存在非洲遗传成分(按ML计为0.00±10.31%;非洲单倍型的9.26%)。

更新日期:2019-07-22
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