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Genetic diversity of HLA system in two populations from Tamaulipas, Mexico: Ciudad Victoria and rural Tamaulipas.
Human Immunology ( IF 3.1 ) Pub Date : 2019-07-22 , DOI: 10.1016/j.humimm.2019.07.288
Tirzo Jesús Rodríguez-Munguía 1 , Rodrigo Barquera 2 , Carmen Adalid-Sáinz 3 , Diana Iraíz Hernández-Zaragoza 4 , Esteban Arrieta-Bolaños 5 , Stephen Clayton 6 , Guadalupe Aquino-Rubio 1 , Marisela Del Rocío González-Martínez 7 , Hanna Pacheco-Ubaldo 8 , Liliana González-Medina 8 , Abraham Lona-Sánchez 8 , Alicia Bravo-Acevedo 9 , Héctor Delgado-Aguirre 3 , Néstor Escareño-Montiel 10 , Yolanda Jaramillo-Rodríguez 11 , Antonio Salgado-Adame 11 , Federico Juárez-de la Cruz 10 , Joaquín Zúñiga 12 , Edmond J Yunis 13 , Carolina Bekker-Méndez 14 , Julio Granados 15
Affiliation  

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 148 Mexicans from the state of Tamaulipas living in Ciudad Victoria (N = 23) and rural communities (N = 125), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Tamaulipas include ten Native American, three European and one African haplotypes. Admixture estimates revealed that the main genetic components in the state of Tamaulipas are Native American (54.69 ± 0.93% by ML; 47.65% of Native American haplotypes) and European (34.66 ± 5.62% by ML; 33.56% of European haplotypes), and a relatively high African genetic component (10.65 ± 5.05% by ML; 12.42% of African haplotypes).



中文翻译:

来自墨西哥塔毛利帕斯州的两个种群中HLA系统的遗传多样性:维多利亚城和塔毛利帕斯农村地区。

我们研究了HLA I类(HLA-A-B)和II类(HLA-DRB1-DQB1)等位基因,通过基于PCR-SSP的方法,从居住在维多利亚城(N = 23)和农村社区(N = 125)的塔毛利帕斯州的148名墨西哥人中获得有关等位基因和单倍型频率的信息。我们发现,塔毛利帕斯州最常见的单倍型包括十个美洲原住民,三个欧洲和一个非洲单倍型。混合物估计显示,塔毛利帕斯州的主要遗传成分是美洲原住民(按ML分类为54.69±0.93%;美国原住民单倍型为47.65%)和欧洲(按ML分类为34.66±5.62%;欧洲单倍型为33.56%),以及相对较高的非洲遗传成分(按ML测得为10.65±5.05%;非洲单倍型的12.42%)。

更新日期:2019-07-22
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