This Special Topics Issue of the journal “Microcirculation” presents seven manuscripts spanning multiple perspectives of investigation. The first two manuscripts present technical/analytical approaches to determining and quantifying vascular network structure, and the third presents a methodology for determining intravascular hemodynamics within the in situ microvascular network. The fourth manuscript utilizes complexity analyses to determine changes in microvascular perfusion as a predictor of disease severity, while the fifth study links the changes to perfusion complexity to tissue metabolic demand and potential limitations on mitochondrial metabolism within skeletal muscle. The sixth manuscript further addresses this critical topic, providing a state‐of‐the‐art discussion of skeletal muscle oxygen kinetics and the factors that impact this vital process. The final manuscript outlines the impact of the deletion of Robo4 on the vascular endothelium on microvascular function in white adipose tissue and the potentially beneficial effects for anti‐obesity treatment. We hope that this presentation of issues of “Complexity in the Microcirculation” will be beneficial to the reader.

中文翻译：

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专题主题：“微循环的复杂性”。

本期《微循环》杂志的专题刊物提出了七份手稿，涵盖了多种研究视角。前两个手稿介绍了确定和量化血管网络结构的技术/分析方法，第三个手稿介绍了用于确定原位微血管网络内血管内血流动力学的方法。第四篇论文利用复杂性分析来确定微血管灌注的变化，作为疾病严重程度的预测指标，而第五篇研究则将灌注复杂性的变化与组织代谢需求和骨骼肌线粒体代谢的潜在限制联系起来。第六手稿进一步探讨了这个关键主题，提供有关骨骼肌氧动力学和影响这一重要过程的因素的最新技术讨论。最后的稿件概述了删除Robo4在白色脂肪组织中对血管内皮的微血管功能以及抗肥胖症治疗的潜在有益作用。我们希望“微循环的复杂性”问题的介绍将对读者有所帮助。