当前位置: X-MOL 学术Biomarkers › 论文详情
Identification of acute myocardial infarction in elderly patients using optimized highly sensitive troponin I thresholds.
Biomarkers ( IF 1.730 ) Pub Date : 2019-06-13 , DOI: 10.1080/1354750x.2019.1606276
Beatrice von Jeinsen,Christoph Liebetrau,Lars Palapies,Stergios Tzikas,Tanja Zeller,Christoph Bickel,Alexander Schmidt,Marco Tubaro,Karl J Lackner,Fachrie Sar,Stephan Baldus,Andreas M Zeiher,Stefan Blankenberg,Tommaso Gori,Thomas Münzel,Christian W Hamm,Philipp S Wild,Till Keller

Purpose: Established diagnostic thresholds for high-sensitivity cardiac troponins (hs-cTn) might not apply for elderly patients as they are elevated irrespective of the presence of an acute myocardial infarction (AMI). Aim of the present study was to investigate hs-cTnI in elderly patients with suspected AMI and to calculate optimized diagnostic cutoffs. Material and methods: Data from a prospective multi-centre study and from a second independent prospective single-centre cohort study were analysed. A number of 2903 patients were eligible for further analysis. Patients > 70 years were classified as elderly. hs-cTnI was measured upon admission. Results: Around 34.7% of 2903 patients were classified as elderly. Around 22.5% of elderly patients were finally diagnosed with AMI. Elderly patients had higher hs-cTnI levels at admission irrespective of the final diagnosis (p < 0.001). According to the AUROC, hs-cTnI was a strong marker for detection of AMI in elderly patients. Application of the 99th percentile cutoffs showed a substantially lower specificity in elderly. By using optimized thresholds, specificity was improved to levels as in younger patients in both cohorts but accompanied with a decrease in sensitivity. Conclusions: hs-cTnI levels have a lower specificity for detecting AMI in elderly patients. This lower specificity can be improved by using hs-cTnI thresholds optimized for elderly patients.
更新日期:2019-11-01

 

全部期刊列表>>
聚焦商业经济政治法律
智控未来
控制与机器人
化学研究精选
欢迎探索2019年最具下载量的地球科学论文
招募海内外科研人才,上自然官网
基因组学对精准公共卫生的影响,专辑征稿
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
湖南大学化学化工学院刘松
上海有机所
李旸
大连化物所
香港大学
X-MOL
支志明
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug